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- W2295485931 abstract "To identify if pregnancy outcomes differ in patients that make multiple euploid embryos from a single in vitro fertilization (IVF) cycle in comparison to patients who make only one. Retrospective Cohort Study Global retrospective IRB was obtained. All patients who underwent IVF with preimplantation genetic screening (PGS) with array comparative genomic hybridization (aCGH), with at least one euploid embryo were included. The first single euploid frozen embryo transfer cycle following the IVF cycle was included. All causes of infertility, all indications for PGS, autologous and donor cycles were included. Patients who elected to undergo two or more euploid embryo transfer cycles were excluded. The primary outcome of the study included pregnancy (presence of a gestational sac) and clinical pregnancy (presence of fetal heart beat through cycle day 63 or a live birth). Statistical analysis was done using ANOVA, t-test and a linear regression model. A total of 327 single euploid embryo transfers were included. The average age of patients included in the study was 37.37 ± 4.90. The overall pregnancy rate was 68.50%(224/327), of which 61.47% (201/327) led to ongoing clinical pregnancies or live births. The most common number of euploid embryos per cohort was one (n=108) with the highest number being 20 (n=1). There was no difference in pregnancy rates when embryos from cycles with multiple euploid embryos were compared to cycles with only one euploid embryo (RR 0.9965, CI 0.8872-1.119, p 0.9457). Linear regression showed no difference was found in pregnancy rates when the percentage of euploid embryos per cohort was compared as well (R =0.0905). There was a significant difference in pregnancy rates in embryos of higher-grade inner cell mass, however when controlled for embryo grades no difference was noted in pregnancy rates in lower numbered euploid embryo cohorts.Tabled 1Pregnancy Outcomes by Number of Euploid Embryos per IVF cycle.Number of EuploidTota Patients (n = 327)Average Number of Eggs RetrievedTotal Pregnant (presence of gestational sac)PercentTotal Clinical Pregnancies (Fetal heart beat or live birth)Percent110812.32 +/- 5.757065656028415.60 +/- 7.236274556534215.79 +/- 6.912969256043019.30 +/- 7.632273217051622.56 +/- 9.921063106361322.38 +/- 8.9196975471327.50 +/- 5.096465388 or more2130.0 +/- 10.7816761362p valuep 0.552p 0.552p 0.676 Open table in a new tab The number or percentage of euploid embryos per IVF cycle, is not associated with the pregnancy outcome of STEET." @default.
- W2295485931 created "2016-06-24" @default.
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- W2295485931 date "2015-09-01" @default.
- W2295485931 modified "2023-09-29" @default.
- W2295485931 title "Does the number of euploid embryos that a patient makes have an affect on the pregnancy outcome of a single thawed euploid embryo transfer (STEET)?" @default.
- W2295485931 doi "https://doi.org/10.1016/j.fertnstert.2015.07.894" @default.
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