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- W2295490622 abstract "In this paper we demonstrate an efficient and non-interfering computational method for Hepatitis B virus (Hep-B) detection on nanoporous silicon oxide impedance immunosensor by employing noise spectroscopy analysis at the peak frequency and show experimentally that it is capable of ultra sensitive label free detection of Hep-B virus in blood through antibody-antigen interactions not only by change in impedance values but also by a different mechanism of shift in peak frequency corresponding to maximum sensitivity. These features allow direct handling of blood serum without the need for pre-concentration or centrifugation, rendering capability for point-of care (POC) application. Further, an embedded electronic interface has been designed with a microcontroller processing the steady state impedance signals and a digital signal processing (DSP) unit handling the noise spectroscopy of the transient fluctuations. The DSP communicates with the microcontroller to display the final output concentration of Hep-B virus in a LCD. The proposed system has been tested with 1fg/ml to 1pg/ml Hep-B virus spiked in blood." @default.
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- W2295490622 date "2016-01-01" @default.
- W2295490622 modified "2023-09-25" @default.
- W2295490622 title "Nanostructured Silicon Oxide Immunosensor Integrated with Noise Spectroscopy Electronics for POC Diagnostics" @default.
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- W2295490622 doi "https://doi.org/10.1109/vlsid.2016.53" @default.
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