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• W229561813 abstract "No AccessJournal of UrologyOriginal Articles1 Apr 1992Citraturic Response to Oral Citric Acid Load Khashayar Sakhaee, Robert Alpern, John Poindexter, and Charles Y.C. Pak Khashayar SakhaeeKhashayar Sakhaee More articles by this author , Robert AlpernRobert Alpern More articles by this author , John PoindexterJohn Poindexter More articles by this author , and Charles Y.C. PakCharles Y.C. Pak More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)37437-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail It is possible that some orally administered citrate may appear in urine by escaping oxidation in vivo. To determine whether this mechanism contributes to the citraturic response to potassium citrate, we measured serum and urinary citrate for 4hours after a single oral load of citric acid (40 mEq.) in 6 normal subjects. Since citric acid does not alter acid-base balance, the effect of absorbed citrate could be isolated from that of alkali load. Serum citrate concentration increased significantly (p <0.05) 30 minutes after a single oral dose of citric acid and remained significantly elevated for 3hours after citric acid load. Commensurate with this change, urinary citrate excretion peaked at 2hours and gradually decreased during the next 2hours after citric acid load. In contrast, serum and urinary citrate remained unaltered following the control load (no drug). Differences of the citratemic and citraturic effects between phases were significant (p <0.05) at 2 and 3hours. Urinary pH, carbon dioxide pressure, bicarbonate, total carbon dioxide and ammonium did not change at any time after citric acid load, and did not differ between the 2 phases. No significant difference was noted in serum electrolytes, arterialized venous pH and carbon dioxide pressure at any time after citric acid load and between the 2 phases. Thus, the citraturic and citratemic effects of oral citric acid are largely accountable by provision of absorbed citrate, which has escaped in vivo degradation. © 1992 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byWong D, Elson L, Nottingham C and Desai A (2022) Pharmaceutical versus Over-the-Counter Potassium Citrate: A Benchtop ComparisonUrology Practice, VOL. 9, NO. 3, (205-211), Online publication date: 1-May-2022.Doizi S, Poindexter J, Pearle M, Blanco F, Moe O, Sakhaee K and Maalouf N (2018) Impact of Potassium Citrate vs Citric Acid on Urinary Stone Risk in Calcium Phosphate Stone FormersJournal of Urology, VOL. 200, NO. 6, (1278-1284), Online publication date: 1-Dec-2018.Eisner B, Asplin J, Goldfarb D, Ahmad A and Stoller M (2010) Citrate, Malate and Alkali Content in Commonly Consumed Diet Sodas: Implications for Nephrolithiasis TreatmentJournal of Urology, VOL. 183, NO. 6, (2419-2423), Online publication date: 1-Jun-2010.Kang D, Sur R, Haleblian G, Fitzsimons N, Borawski K and Preminger G (2018) Long-Term Lemonade Based Dietary Manipulation in Patients With Hypocitraturic NephrolithiasisJournal of Urology, VOL. 177, NO. 4, (1358-1362), Online publication date: 1-Apr-2007.GETTMAN M, OGAN K, BRINKLEY L, ADAMS-HUET B, PAK C and PEARLE M (2018) EFFECT OF CRANBERRY JUICE CONSUMPTION ON URINARY STONE RISK FACTORSJournal of Urology, VOL. 174, NO. 2, (590-594), Online publication date: 1-Aug-2005.SAKHAEE K, POINDEXTER J, GRIFFITH C and PAK C (2018) STONE FORMING RISK OF CALCIUM CITRATE SUPPLEMENTATION IN HEALTHY POSTMENOPAUSAL WOMENJournal of Urology, VOL. 172, NO. 3, (958-961), Online publication date: 1-Sep-2004.TEKIN A, TEKGUL S, ATSU N, BAKKALOGLU M and KENDI S (2018) Oral Potassium Citrate Treatment for Idiopathic Hypocitruria in Children With Calcium UrolithiasisJournal of Urology, VOL. 168, NO. 6, (2572-2574), Online publication date: 1-Dec-2002.Seltzer M, Low R, McDonald M, Shami G and Stoller M (2018) Dietary Manipulation With Lemonade to Treat Hypocitraturic Calcium NephrolithiasisJournal of Urology, VOL. 156, NO. 3, (907-909), Online publication date: 1-Sep-1996. Volume 147Issue 4April 1992Page: 975-976 Advertisement Copyright & Permissions© 1992 by The American Urological Association Education and Research, Inc.Keywordscitric acidurinary calculicitratesMetricsAuthor Information Khashayar Sakhaee More articles by this author Robert Alpern More articles by this author John Poindexter More articles by this author Charles Y.C. Pak More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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