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- W2295671330 endingPage "74" @default.
- W2295671330 startingPage "69" @default.
- W2295671330 abstract "Neural stem and progenitor cells (NSC/NPCs) are unspecialized cells found in the adult peri-ventricular and sub-granular zones that are capable of self-renewal, migration, and differentiation into new neurons through the remarkable process of postnatal neurogenesis. We are now beginning to understand that the concerted action of ion channels, multi-pass transmembrane proteins that allow passage of ions across otherwise impermeable cellular membranes tightly regulate this process. Specific ion channels control proliferation, differentiation and survival. Furthermore, they have the potential to be highly selective drug targets due to their complex structures. As such, these proteins represent intriguing prospects for control and optimization of postnatal neurogenesis for neural regeneration following brain injury or disease. Here, we concentrate on ion channels identified in adult ventricular zone NSC/NPCs that have been found to influence the stages of neurogenesis. Finally, we outline the potential of these channels to elicit repair, and highlight the outstanding challenges." @default.
- W2295671330 created "2016-06-24" @default.
- W2295671330 creator A5043544825 @default.
- W2295671330 creator A5061498277 @default.
- W2295671330 date "2012-03-01" @default.
- W2295671330 modified "2023-10-18" @default.
- W2295671330 title "Ion channels in postnatal neurogenesis" @default.
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- W2295671330 doi "https://doi.org/10.4161/chan.19721" @default.
- W2295671330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22614818" @default.
- W2295671330 hasPublicationYear "2012" @default.
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