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- W2295777772 endingPage "140" @default.
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- W2295777772 abstract "The mevalonate cascade is a key metabolic pathway that regulates a variety of cellular functions and is thereby implicated in the pathophysiology of most brain diseases, including neurodevelopmental and neurodegenerative disorders. Emerging lines of evidence suggest that statins and Rho GTPase inhibitors are efficacious and have advantageous properties in treatment of different pathologic conditions that are relevant to the central nervous system. Beyond the original role of statins in lowering cholesterol synthesis, they have anti-inflammatory, antioxidant and modulatory effects on signaling pathways. Additionally, Rho GTPase inhibitors and statins share the mevalonate pathway as a common target of their therapeutic actions. In this review, we discuss potential mechanisms through which these drugs, via their role in the mevalonate pathway, exert their neuroprotective effects in neurodegenerative and neurodevelopmental disorders. Keywords: Cholesterol, neurodegeneration, neurodevelopment, Rho GTPase, statins." @default.
- W2295777772 created "2016-06-24" @default.
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- W2295777772 date "2017-03-01" @default.
- W2295777772 modified "2023-09-26" @default.
- W2295777772 title "Mevalonate Cascade and Neurodevelopmental and Neurodegenerative Diseases: Future Targets for Therapeutic Application" @default.
- W2295777772 cites W105623059 @default.
- W2295777772 cites W1520122966 @default.
- W2295777772 cites W1520904574 @default.
- W2295777772 cites W1524495606 @default.
- W2295777772 cites W1548831745 @default.
- W2295777772 cites W1567127662 @default.
- W2295777772 cites W1568960993 @default.
- W2295777772 cites W1588992473 @default.
- W2295777772 cites W1606372460 @default.
- W2295777772 cites W1616421194 @default.
- W2295777772 cites W1749911542 @default.
- W2295777772 cites W1869181316 @default.
- W2295777772 cites W1880941604 @default.
- W2295777772 cites W1890581590 @default.
- W2295777772 cites W1927300786 @default.
- W2295777772 cites W1927965099 @default.
- W2295777772 cites W1965050626 @default.
- W2295777772 cites W1965703692 @default.
- W2295777772 cites W1966330282 @default.
- W2295777772 cites W1966460916 @default.
- W2295777772 cites W1967516512 @default.
- W2295777772 cites W1971819432 @default.
- W2295777772 cites W1974878596 @default.
- W2295777772 cites W1975454216 @default.
- W2295777772 cites W1976152949 @default.
- W2295777772 cites W1976551834 @default.
- W2295777772 cites W1976749972 @default.
- W2295777772 cites W1977252372 @default.
- W2295777772 cites W1977300801 @default.
- W2295777772 cites W1977595948 @default.
- W2295777772 cites W1978993923 @default.
- W2295777772 cites W1979444935 @default.
- W2295777772 cites W1980857453 @default.
- W2295777772 cites W1981397772 @default.
- W2295777772 cites W1982030535 @default.
- W2295777772 cites W1988620153 @default.
- W2295777772 cites W1989687646 @default.
- W2295777772 cites W1989903772 @default.
- W2295777772 cites W1991357832 @default.
- W2295777772 cites W1991530671 @default.
- W2295777772 cites W1991583073 @default.
- W2295777772 cites W1991867131 @default.
- W2295777772 cites W1992865216 @default.
- W2295777772 cites W1992871875 @default.
- W2295777772 cites W1993032177 @default.
- W2295777772 cites W1993163864 @default.
- W2295777772 cites W1994662145 @default.
- W2295777772 cites W1994756206 @default.
- W2295777772 cites W1995111180 @default.
- W2295777772 cites W1995291424 @default.
- W2295777772 cites W1997378060 @default.
- W2295777772 cites W1999228896 @default.
- W2295777772 cites W1999893655 @default.
- W2295777772 cites W1999895981 @default.
- W2295777772 cites W1999935530 @default.
- W2295777772 cites W2000866886 @default.
- W2295777772 cites W2001004870 @default.
- W2295777772 cites W2001082025 @default.
- W2295777772 cites W2002506451 @default.
- W2295777772 cites W2003753329 @default.
- W2295777772 cites W2006161539 @default.
- W2295777772 cites W2006166262 @default.
- W2295777772 cites W2007081989 @default.
- W2295777772 cites W2007263766 @default.
- W2295777772 cites W2007445504 @default.
- W2295777772 cites W2007820992 @default.
- W2295777772 cites W2007960303 @default.
- W2295777772 cites W2009001438 @default.
- W2295777772 cites W2009967691 @default.
- W2295777772 cites W2012636039 @default.
- W2295777772 cites W2014000620 @default.
- W2295777772 cites W2014218783 @default.
- W2295777772 cites W2015556961 @default.
- W2295777772 cites W2015808932 @default.
- W2295777772 cites W2016152013 @default.
- W2295777772 cites W2017289592 @default.
- W2295777772 cites W2017885661 @default.
- W2295777772 cites W2019731805 @default.