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- W2295809719 endingPage "88" @default.
- W2295809719 startingPage "77" @default.
- W2295809719 abstract "To promote the tumor growth, angiogenesis, metabolism, and invasion, glioblastoma (GBM) cells subvert the surrounding microenvironment by influencing the endogenous activity of other brain cells including endothelial cells, macrophages, astrocytes, and microglia. Large number of studies indicates that the intra-cellular communication between the different cell types of the GBM microenvironment occurs through the functional transfer of oncogenic components such as proteins, non-coding RNAs, DNA and lipids via the release and uptake of extracellular vesicles (EVs). Unlike the communication through the secretion of chemokines and cytokines, the transfer and gene silencing activity of microRNAs through EVs is more complex as the biogenesis and proper packaging of microRNAs is crucial for their uptake by recipient cells. Although the specific mechanism of EV-derived microRNA uptake and processing in recipient cells is largely unknown, the screening, identifying and finally targeting of the EV-associated pro-tumorigenic microRNAs are emerging as new therapeutic strategy to combat the GBM." @default.
- W2295809719 created "2016-06-24" @default.
- W2295809719 creator A5001805306 @default.
- W2295809719 creator A5062551006 @default.
- W2295809719 creator A5080823075 @default.
- W2295809719 date "2016-03-11" @default.
- W2295809719 modified "2023-09-25" @default.
- W2295809719 title "MicroRNA and extracellular vesicles in glioblastoma: small but powerful" @default.
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