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• W2295919652 startingPage "251" @default.
• W2295919652 abstract "The aim of this work was to establish the micro RNA profile of SNK 6 and SNT 16, two Epstein–Barr virus ( EBV )‐infected cell lines derived from nasal NK /T‐cell lymphoma ( NKTL ). The oncogenic EBV is strongly associated with the pathogenesis of nasal and extranodal NK /T‐cell lymphoma and expresses 44 mature micro RNA s and two noncoding EBV ‐encoded RNA s ( EBER s). mi RNA s are 19‐25nt noncoding RNA s that affect host and viral gene expression post‐transcriptionally. Deregulated mi RNA patterns are frequently linked to a variety of human cancers including lymphomas. mi RNA profiling of the two NK /T cell lines vs. primary cells revealed 10 and 4 up‐regulated and 10 and 12 down‐regulated mi RNA s in SNK 6 and SNT 16 cells respectively. The results were validated by qRT ‐ PCR for selected mi RNA s. Target gene analyses confirmed cullin 5 ( CUL 5) and sphingosin‐1‐phosphate receptor 1 (S1 PR 1) as targets for the down‐regulated hsa‐miR‐148a and viral ebv‐miR‐ BART 16 respectively. As recently demonstrated for the regulation of IL 1‐alpha by miR‐142‐3p, coexpression of the EBER s selectively exerted corepression of S1 PR 1 by BART 16 but not of CUL 5 by miR‐148a, indicating selective corepression by the EBER s." @default.
• W2295919652 created "2016-06-24" @default.
• W2295919652 creator A5021006948 @default.
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• W2295919652 date "2016-02-27" @default.
• W2295919652 modified "2023-10-04" @default.
• W2295919652 title "miRNA expression profiling of Epstein-Barr virus-associated NKTL cell lines by Illumina deep sequencing" @default.
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• W2295919652 doi "https://doi.org/10.1002/2211-5463.12027" @default.
• W2295919652 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4821355" @default.
• W2295919652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27239439" @default.
• W2295919652 hasPublicationYear "2016" @default.
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