FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2296007828> ?p ?o ?g. }

• W2296007828 endingPage "1388" @default.
• W2296007828 startingPage "1371" @default.
• W2296007828 abstract "In PET imaging, research groups have recently proposed different experimental set ups allowing multiple animals to be simultaneously imaged in a scanner in order to reduce the costs and increase the throughput. In those studies, the technical feasibility was demonstrated and the signal degradation caused by additional mice in the FOV characterized, however, the impact of the signal degradation on the outcome of a PET study has not yet been studied. Here we thoroughly investigated, using Monte Carlo simulated [18F]FDG and [11C]Raclopride PET studies, different experimental designs for whole-body and brain acquisitions of two mice and assessed the actual impact on the detection of biological variations as compared to a single-mouse setting. First, we extended the validation of the PET-SORTEO Monte Carlo simulation platform for the simultaneous simulation of two animals. Then, we designed [18F]FDG and [11C]Raclopride input mouse models for the simulation of realistic whole-body and brain PET studies. Simulated studies allowed us to accurately estimate the differences in detection between single- and dual-mode acquisition settings that are purely the result of having two animals in the FOV. Validation results showed that PET-SORTEO accurately reproduced the spatial resolution and noise degradations that were observed with actual dual phantom experiments. The simulated [18F]FDG whole-body study showed that the resolution loss due to the off-center positioning of the mice was the biggest contributing factor in signal degradation at the pixel level and a minimal inter-animal distance as well as the use of reconstruction methods with resolution modeling should be preferred. Dual mode acquisition did not have a major impact on ROI-based analysis except in situations where uptake values in organs from the same subject were compared. The simulated [11C]Raclopride study however showed that dual-mice imaging strongly reduced the sensitivity to variations when mice were positioned side-by-side while no sensitivity reduction was observed when they were facing each other. This is the first study showing the impact of different experimental designs for whole-body and brain acquisitions of two mice on the quality of the results using Monte Carlo simulated [18F]FDG and [11C]Raclopride PET studies." @default.
• W2296007828 created "2016-06-24" @default.
• W2296007828 creator A5006436645 @default.
• W2296007828 creator A5018992143 @default.
• W2296007828 creator A5020590909 @default.
• W2296007828 creator A5027721760 @default.
• W2296007828 creator A5031560664 @default.
• W2296007828 creator A5035921217 @default.
• W2296007828 creator A5073574648 @default.
• W2296007828 creator A5073863852 @default.
• W2296007828 creator A5084470186 @default.
• W2296007828 creator A5086012797 @default.
• W2296007828 creator A5089439089 @default.
• W2296007828 date "2016-01-21" @default.
• W2296007828 modified "2023-10-14" @default.
• W2296007828 title "Simultaneous scanning of two mice in a small-animal PET scanner: a simulation-based assessment of the signal degradation" @default.
• W2296007828 cites W1981195725 @default.
• W2296007828 cites W1985588963 @default.
• W2296007828 cites W1986532691 @default.
• W2296007828 cites W2027812268 @default.
• W2296007828 cites W2032874357 @default.
• W2296007828 cites W2038018468 @default.
• W2296007828 cites W2050209952 @default.
• W2296007828 cites W2055327071 @default.
• W2296007828 cites W2055894011 @default.
• W2296007828 cites W2066116476 @default.
• W2296007828 cites W2078058880 @default.
• W2296007828 cites W2085873825 @default.
• W2296007828 cites W2159278324 @default.
• W2296007828 doi "https://doi.org/10.1088/0031-9155/61/3/1371" @default.
• W2296007828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26797268" @default.
• W2296007828 hasPublicationYear "2016" @default.
• W2296007828 type Work @default.
• W2296007828 sameAs 2296007828 @default.
• W2296007828 citedByCount "6" @default.
• W2296007828 countsByYear W22960078282020 @default.
• W2296007828 countsByYear W22960078282021 @default.
• W2296007828 countsByYear W22960078282022 @default.
• W2296007828 countsByYear W22960078282023 @default.
• W2296007828 crossrefType "journal-article" @default.
• W2296007828 hasAuthorship W2296007828A5006436645 @default.
• W2296007828 hasAuthorship W2296007828A5018992143 @default.
• W2296007828 hasAuthorship W2296007828A5020590909 @default.
• W2296007828 hasAuthorship W2296007828A5027721760 @default.
• W2296007828 hasAuthorship W2296007828A5031560664 @default.
• W2296007828 hasAuthorship W2296007828A5035921217 @default.
• W2296007828 hasAuthorship W2296007828A5073574648 @default.
• W2296007828 hasAuthorship W2296007828A5073863852 @default.
• W2296007828 hasAuthorship W2296007828A5084470186 @default.
• W2296007828 hasAuthorship W2296007828A5086012797 @default.
• W2296007828 hasAuthorship W2296007828A5089439089 @default.
• W2296007828 hasConcept C104293457 @default.
• W2296007828 hasConcept C105795698 @default.
• W2296007828 hasConcept C115961682 @default.
• W2296007828 hasConcept C154945302 @default.
• W2296007828 hasConcept C19499675 @default.
• W2296007828 hasConcept C199360897 @default.
• W2296007828 hasConcept C205372480 @default.
• W2296007828 hasConcept C2779751349 @default.
• W2296007828 hasConcept C2779843651 @default.
• W2296007828 hasConcept C2989005 @default.
• W2296007828 hasConcept C31972630 @default.
• W2296007828 hasConcept C33923547 @default.
• W2296007828 hasConcept C41008148 @default.
• W2296007828 hasConcept C44154836 @default.
• W2296007828 hasConcept C71924100 @default.
• W2296007828 hasConcept C99498987 @default.
• W2296007828 hasConceptScore W2296007828C104293457 @default.
• W2296007828 hasConceptScore W2296007828C105795698 @default.
• W2296007828 hasConceptScore W2296007828C115961682 @default.
• W2296007828 hasConceptScore W2296007828C154945302 @default.
• W2296007828 hasConceptScore W2296007828C19499675 @default.
• W2296007828 hasConceptScore W2296007828C199360897 @default.
• W2296007828 hasConceptScore W2296007828C205372480 @default.
• W2296007828 hasConceptScore W2296007828C2779751349 @default.
• W2296007828 hasConceptScore W2296007828C2779843651 @default.
• W2296007828 hasConceptScore W2296007828C2989005 @default.
• W2296007828 hasConceptScore W2296007828C31972630 @default.
• W2296007828 hasConceptScore W2296007828C33923547 @default.
• W2296007828 hasConceptScore W2296007828C41008148 @default.
• W2296007828 hasConceptScore W2296007828C44154836 @default.
• W2296007828 hasConceptScore W2296007828C71924100 @default.
• W2296007828 hasConceptScore W2296007828C99498987 @default.
• W2296007828 hasIssue "3" @default.
• W2296007828 hasLocation W22960078281 @default.
• W2296007828 hasLocation W22960078282 @default.
• W2296007828 hasLocation W22960078283 @default.
• W2296007828 hasLocation W22960078284 @default.
• W2296007828 hasLocation W22960078285 @default.
• W2296007828 hasOpenAccess W2296007828 @default.
• W2296007828 hasPrimaryLocation W22960078281 @default.
• W2296007828 hasRelatedWork W1883703893 @default.
• W2296007828 hasRelatedWork W1969509093 @default.
• W2296007828 hasRelatedWork W1975030924 @default.
• W2296007828 hasRelatedWork W2044788131 @default.
• W2296007828 hasRelatedWork W2079877841 @default.
• W2296007828 hasRelatedWork W2778298633 @default.
• W2296007828 hasRelatedWork W2900723815 @default.

• next