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• W2296013553 abstract "The Rho/Rho kinase pathway plays a crucial role in the development of cardiac hypertrophy and failure. There are 2 isoforms of Rho-kinase, ROCK1 and ROCK2, and they have different functions in cardiac tissues (e.g. ECs, VSMCs, cardiomyocytes, cardiac fibroblasts, and inflammatory cells). It has been demonstrated that ROCK2 in cardiomyocytes promotes cardiac hypertrophy and fibrosis in response to pressure-overload. However, the specific roles of ROCK1 in cardiomyocytes have not been elucidated. We performed transverse aortic constriction (TAC) in myocardial-specific ROCK1 knockout (KO) and wild-type (WT) mice, and thereafter examined the time-course for 4 weeks. The time course and localization of ROCK1 and ROCK2 expression after TAC were completely different in WT mice. Western blotting demonstrated significantly reduced ROCK1 expression (-74%) and relative increase of ROCK2 expression (+29%) in KO hearts (n=6) compared with WT hearts (n=9). Mechanistic analyses demonstrated that KO mice tended to show increased activation of ERK1/2, P38 and Akt in KO mice compared with WT mice (+14%, +58% and +35%, respectively). Importantly, KO mice showed vulnerability to pressure-overload with left ventricular dilatation (+17%) and reduced contractility (-46%) compared with WT mice. Finally, KO mice (n=37) showed poor survival compared with WT mice (n=33). These results indicate that ROCK1 plays a crucial role to maintain cardiac function in response to pressure-overload." @default.
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• W2296013553 date "2015-10-01" @default.
• W2296013553 modified "2023-10-15" @default.
• W2296013553 title "ROCK1 Plays a Crucial Role to Maintain Cardiac Function in Response to Pressure-Overload in Mice" @default.
• W2296013553 doi "https://doi.org/10.1016/j.cardfail.2015.08.173" @default.
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