FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2296069419> ?p ?o ?g. }

• W2296069419 endingPage "152" @default.
• W2296069419 startingPage "136" @default.
• W2296069419 abstract "The specific properties of a synapse determine how neuronal activity evokes neurotransmitter release. Evaluating changes in synaptic properties during sustained activity is essential to understanding how genetic manipulations and neuromodulators regulate neurotransmitter release. Analyses of postsynaptic responses to high-frequency stimulation have provided estimates of the size of the readily-releasable pool (RRP) of vesicles (N0) and the probability of vesicular release (p) at multiple synapses.Here, we introduce a model-based approach at the calyx of Held synapse in which depletion and the rate of replenishment (R) determine the number of available vesicles, and facilitation leads to a use-dependent increase in p when initial p is low.When p is high and R is low, we find excellent agreement between estimates based on all three methods and the model. However, when p is low or when significant replenishment occurs between stimuli, estimates of different methods diverge, and model estimates are between the extreme estimates provided by the other approaches.We compare our model-based approach to three other approaches that rely on different simplifying assumptions. Our findings suggest that our model provides a better estimate of N0 and p than previously-established methods, likely due to inaccurate assumptions about replenishment. More generally, our findings suggest that approaches commonly used to estimate N0 and p at other synapses are often applied under experimental conditions that yield inaccurate estimates.Careful application of appropriate methods can greatly improve estimates of synaptic parameters." @default.
• W2296069419 created "2016-06-24" @default.
• W2296069419 creator A5037488240 @default.
• W2296069419 creator A5053791142 @default.
• W2296069419 date "2016-05-01" @default.
• W2296069419 modified "2023-10-08" @default.
• W2296069419 title "Determining synaptic parameters using high-frequency activation" @default.
• W2296069419 cites W1487318093 @default.
• W2296069419 cites W1490183365 @default.
• W2296069419 cites W1601000163 @default.
• W2296069419 cites W1877594537 @default.
• W2296069419 cites W1963580947 @default.
• W2296069419 cites W1964268507 @default.
• W2296069419 cites W1970200112 @default.
• W2296069419 cites W1974015977 @default.
• W2296069419 cites W1983245247 @default.
• W2296069419 cites W2000436563 @default.
• W2296069419 cites W2010679521 @default.
• W2296069419 cites W2010905290 @default.
• W2296069419 cites W2017582927 @default.
• W2296069419 cites W2019016101 @default.
• W2296069419 cites W2022104262 @default.
• W2296069419 cites W2022995207 @default.
• W2296069419 cites W2031543773 @default.
• W2296069419 cites W2032841129 @default.
• W2296069419 cites W2035001975 @default.
• W2296069419 cites W2038470044 @default.
• W2296069419 cites W2044797107 @default.
• W2296069419 cites W2047397502 @default.
• W2296069419 cites W2047730591 @default.
• W2296069419 cites W2049514910 @default.
• W2296069419 cites W2052006707 @default.
• W2296069419 cites W2057136600 @default.
• W2296069419 cites W2061619102 @default.
• W2296069419 cites W2064899640 @default.
• W2296069419 cites W2065626695 @default.
• W2296069419 cites W2068105241 @default.
• W2296069419 cites W2068961612 @default.
• W2296069419 cites W2069764948 @default.
• W2296069419 cites W2073391931 @default.
• W2296069419 cites W2076883859 @default.
• W2296069419 cites W2081530370 @default.
• W2296069419 cites W2093550903 @default.
• W2296069419 cites W2095352259 @default.
• W2296069419 cites W2097574751 @default.
• W2296069419 cites W2100056505 @default.
• W2296069419 cites W2103048971 @default.
• W2296069419 cites W2103787070 @default.
• W2296069419 cites W2105172681 @default.
• W2296069419 cites W2107092259 @default.
• W2296069419 cites W2112927743 @default.
• W2296069419 cites W2115030010 @default.
• W2296069419 cites W2116573581 @default.
• W2296069419 cites W2118064450 @default.
• W2296069419 cites W2122383890 @default.
• W2296069419 cites W2125752525 @default.
• W2296069419 cites W2129696839 @default.
• W2296069419 cites W2134343364 @default.
• W2296069419 cites W2134590664 @default.
• W2296069419 cites W2139055855 @default.
• W2296069419 cites W2139621297 @default.
• W2296069419 cites W2142604892 @default.
• W2296069419 cites W2153499119 @default.
• W2296069419 cites W2153700958 @default.
• W2296069419 cites W2155535919 @default.
• W2296069419 cites W2158561409 @default.
• W2296069419 cites W2159979661 @default.
• W2296069419 cites W2162668311 @default.
• W2296069419 cites W2165544326 @default.
• W2296069419 cites W2168869282 @default.
• W2296069419 cites W2170612760 @default.
• W2296069419 cites W2339906229 @default.
• W2296069419 cites W2416491965 @default.
• W2296069419 cites W4210360421 @default.
• W2296069419 doi "https://doi.org/10.1016/j.jneumeth.2016.02.021" @default.
• W2296069419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4833598" @default.
• W2296069419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26972952" @default.
• W2296069419 hasPublicationYear "2016" @default.
• W2296069419 type Work @default.
• W2296069419 sameAs 2296069419 @default.
• W2296069419 citedByCount "46" @default.
• W2296069419 countsByYear W22960694192016 @default.
• W2296069419 countsByYear W22960694192017 @default.
• W2296069419 countsByYear W22960694192018 @default.
• W2296069419 countsByYear W22960694192019 @default.
• W2296069419 countsByYear W22960694192020 @default.
• W2296069419 countsByYear W22960694192021 @default.
• W2296069419 countsByYear W22960694192022 @default.
• W2296069419 countsByYear W22960694192023 @default.
• W2296069419 crossrefType "journal-article" @default.
• W2296069419 hasAuthorship W2296069419A5037488240 @default.
• W2296069419 hasAuthorship W2296069419A5053791142 @default.
• W2296069419 hasBestOaLocation W22960694192 @default.
• W2296069419 hasConcept C127445978 @default.
• W2296069419 hasConcept C130316041 @default.
• W2296069419 hasConcept C1337776 @default.
• W2296069419 hasConcept C148785051 @default.
• W2296069419 hasConcept C169760540 @default.

• next