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- W2296082007 abstract "To demonstrate anti-hyperlipidemic activity of the 19α-hydroxyursane-type triterpenoid (19α-HUT)-rich fraction, this fraction was prepared from the extract of Rubus crataegifolius leaves. This fraction was found to have anti-hyperlipidemic effect in a high fat diet-induced rat model from the observation of reduction of abdominal fat pad weights, atherogenic index and hypercholesterolemia at 30 and 60 mg/kg (p.o.) The 19α-HUT fraction was subjected to SiO2, ODS, and/or Sephadex LH-20 column chromatography to yield a new triterpenoid (1) called pomolic acid ester along with nine known triterpenoids which are all 19α-HUTs: euscaphic acid (2), tormentic acid (3), 23-hydroxytormentic acid (4), kaji-ichigoside F1 (5), rosamultin (6), niga-ichigosides F1 (7) and F2 (8), suavissimoside F1 (9) and coreanoside F1 (10). The structure of compound 1 was established as 28-Oformyl-3,19-dihydroxyurs-12-en-28-oic acid on the basis of 2D-NMR spectroscopic data and mass spectrum. Compound 1 was isolated for the first time from natural sources." @default.
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- W2296082007 date "2007-01-01" @default.
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- W2296082007 title "The Anti-hyperlipidemic Effect and Constituents of the 19α-Hydroxyursane-type Triterpenoid fraction Obtained from the Leaves of Rubus crataegifolius" @default.
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