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- W2296096317 abstract "In combination with other agents, rifampin is considered the key ingredient in the modern chemotherapy for Mycobacteria tuberculosis. However, infrequently, it may be associated with severe adverse reactions, such as hepatitis, acute renal failure, hemolytic anemia, and thrombocytopenia. Rifampin-induced thrombocytopenia is a rare event and traditionally has been considered to be related to intermittent treatment in higher doses. The incidence is extremely low if the treatment is given on a daily basis. The exact pathogenesis of rifampin-induced thrombocytopenia is still not fully understood, but an immune complex-mediated mechanism composed of rifampin and rifampin-dependent antibody binding to platelets has been postulated to explain this phenomenon. We report a 70-year-old woman who had been treated on a daily basis for pulmonary tuberculosis, but incompletely, and then developed life-threatening thrombocytopenia immediately after the reintroduction of rifampin. An explosive oral mucosal bleeding and generalized petechiae were noted 3 to 4 hours after the rifampicin rechallenge. Rifampin-induced thrombocytopenia is potentially life-threatening, though it is extremely rare, especially with a single, small dose of the drug. We herein present an unusual case and emphasize the importance of this easily overlooked rifampin rechallenge-related thrombocytopenia." @default.
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- W2296096317 date "2005-08-01" @default.
- W2296096317 modified "2023-10-17" @default.
- W2296096317 title "Life-threatening Thrombocytopenia after Rifampin Rechallenge in Tuberculosis-A Case Report and Literature Review" @default.
- W2296096317 doi "https://doi.org/10.29806/tm.200508.0006" @default.
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