Matches in SemOpenAlex for { <https://semopenalex.org/work/W2296152572> ?p ?o ?g. }
- W2296152572 abstract "Phosphatase of regenerating liver-3 (PRL-3) has been reported to be associated with colon and gastric cancer metastasis. However, the role and function of PRL-3 in human non-small cell lung cancer cells is unknown. Our studies showed that the expression of PRL-3mRNA and protein are higher in less invasive human lung adenocarcinoma cells than in highly invasive cell lines. Ectopic expression of PRL-3 reduced cell capacity for anchorage-dependent growth, anchorage-independent growth, migration, and invasion in vitro, as well as tumorigenesis in vivo. Conversely, catalytic (C104S) and prenylation-site (C170S) mutants enhanced cell invasion. Microarray profiling of PRL-3 transfectants revealed the pathways potentially involving PRL-3, including the epithelial-mesenchymal transition (EMT), extracellular matrix remodeling, and the WNT signaling pathway. Furthermore, we demonstrated that increased PRL-3 reduced Slug and enhanced E-cadherin gene expression through the AKT/GSK3β/β-catenin pathway. In conclusion, our data suggest that PRL-3 might play a tumor suppressor role in lung cancer, distinct from other cancers, by inhibiting EMT-related pathways." @default.
- W2296152572 created "2016-06-24" @default.
- W2296152572 creator A5012323009 @default.
- W2296152572 creator A5050840929 @default.
- W2296152572 creator A5054716842 @default.
- W2296152572 creator A5073440860 @default.
- W2296152572 creator A5091640201 @default.
- W2296152572 date "2016-03-08" @default.
- W2296152572 modified "2023-10-14" @default.
- W2296152572 title "Phosphatase of regenerating liver-3 inhibits invasiveness and proliferation in non-small cell lung cancer by regulating the epithelial-mesenchymal transition" @default.
- W2296152572 cites W1481453425 @default.
- W2296152572 cites W1521798220 @default.
- W2296152572 cites W1693243095 @default.
- W2296152572 cites W1865303423 @default.
- W2296152572 cites W1968338321 @default.
- W2296152572 cites W1969875009 @default.
- W2296152572 cites W1977215066 @default.
- W2296152572 cites W1979538859 @default.
- W2296152572 cites W1993312546 @default.
- W2296152572 cites W1999315653 @default.
- W2296152572 cites W2002376765 @default.
- W2296152572 cites W2006334733 @default.
- W2296152572 cites W2012034410 @default.
- W2296152572 cites W2014247568 @default.
- W2296152572 cites W2015008880 @default.
- W2296152572 cites W2016816357 @default.
- W2296152572 cites W2017104633 @default.
- W2296152572 cites W2017593808 @default.
- W2296152572 cites W2017771389 @default.
- W2296152572 cites W2020126761 @default.
- W2296152572 cites W2028617170 @default.
- W2296152572 cites W2035732765 @default.
- W2296152572 cites W2038929851 @default.
- W2296152572 cites W2043617798 @default.
- W2296152572 cites W2044573147 @default.
- W2296152572 cites W2045208917 @default.
- W2296152572 cites W2046426607 @default.
- W2296152572 cites W2052659086 @default.
- W2296152572 cites W2067024032 @default.
- W2296152572 cites W2067937569 @default.
- W2296152572 cites W2074547047 @default.
- W2296152572 cites W2082285717 @default.
- W2296152572 cites W2089344415 @default.
- W2296152572 cites W2104169873 @default.
- W2296152572 cites W2106112270 @default.
- W2296152572 cites W2111890489 @default.
- W2296152572 cites W2112928874 @default.
- W2296152572 cites W2120294133 @default.
- W2296152572 cites W2124060121 @default.
- W2296152572 cites W2127965293 @default.
- W2296152572 cites W2132165198 @default.
- W2296152572 cites W2132672953 @default.
- W2296152572 cites W2136862034 @default.
- W2296152572 cites W2138537942 @default.
- W2296152572 cites W2143163950 @default.
- W2296152572 cites W2144265114 @default.
- W2296152572 cites W2148361096 @default.
- W2296152572 cites W2162702011 @default.
- W2296152572 cites W4232719563 @default.
- W2296152572 cites W92559662 @default.
- W2296152572 doi "https://doi.org/10.18632/oncotarget.7985" @default.
- W2296152572 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5008324" @default.
- W2296152572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26967563" @default.
- W2296152572 hasPublicationYear "2016" @default.
- W2296152572 type Work @default.
- W2296152572 sameAs 2296152572 @default.
- W2296152572 citedByCount "8" @default.
- W2296152572 countsByYear W22961525722016 @default.
- W2296152572 countsByYear W22961525722017 @default.
- W2296152572 countsByYear W22961525722018 @default.
- W2296152572 countsByYear W22961525722019 @default.
- W2296152572 countsByYear W22961525722020 @default.
- W2296152572 crossrefType "journal-article" @default.
- W2296152572 hasAuthorship W2296152572A5012323009 @default.
- W2296152572 hasAuthorship W2296152572A5050840929 @default.
- W2296152572 hasAuthorship W2296152572A5054716842 @default.
- W2296152572 hasAuthorship W2296152572A5073440860 @default.
- W2296152572 hasAuthorship W2296152572A5091640201 @default.
- W2296152572 hasBestOaLocation W22961525721 @default.
- W2296152572 hasConcept C121608353 @default.
- W2296152572 hasConcept C137620995 @default.
- W2296152572 hasConcept C2779013556 @default.
- W2296152572 hasConcept C502942594 @default.
- W2296152572 hasConcept C54355233 @default.
- W2296152572 hasConcept C555283112 @default.
- W2296152572 hasConcept C62112901 @default.
- W2296152572 hasConcept C62478195 @default.
- W2296152572 hasConcept C75217442 @default.
- W2296152572 hasConcept C76419328 @default.
- W2296152572 hasConcept C81885089 @default.
- W2296152572 hasConcept C86803240 @default.
- W2296152572 hasConcept C95444343 @default.
- W2296152572 hasConcept C97037327 @default.
- W2296152572 hasConceptScore W2296152572C121608353 @default.
- W2296152572 hasConceptScore W2296152572C137620995 @default.
- W2296152572 hasConceptScore W2296152572C2779013556 @default.
- W2296152572 hasConceptScore W2296152572C502942594 @default.
- W2296152572 hasConceptScore W2296152572C54355233 @default.
- W2296152572 hasConceptScore W2296152572C555283112 @default.
- W2296152572 hasConceptScore W2296152572C62112901 @default.