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- W2296209892 abstract "Effects of the extract and fractions from Parasenecio pseudotaimingasa on rat lens aldose reductase (AR) inhibition have been investigated. Among them, the n-BuOH fraction was exhibited good inhibitory potencies (IC50 value 1.42 μg/ml). Phytochemical constituents were isolated from the n-BuOH fraction by open column chromatography. Their structures were elucidated as luteolin-7-O-rutinoside (1) and luteolin-7-Oglucoside (2) on the basis of spectroscopic analysis. Compounds 1 and 2 exhibited strong AR inhibitory activity, with IC50 values of 2.37 and 1.05 μM, respectively. This is the first report on the isolation of compounds 1 and 2 from P. pseudotaimingasa. These results suggest that P. pseudotaimingasa could be a useful material in the development of a novel AR inhibitory agent against diabetic complications." @default.
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- W2296209892 date "2011-12-01" @default.
- W2296209892 modified "2023-09-25" @default.
- W2296209892 title "Aldose Reductase Inhibition by Luteolin Derivatives from Parasenecio pseudotaimingasa" @default.
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