FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2296222259> ?p ?o ?g. }

• W2296222259 endingPage "1183" @default.
• W2296222259 startingPage "1167" @default.
• W2296222259 abstract "Abstract Since the discovery of microRNAs (miRNAs) only two decades ago, they have emerged as an essential component of the gene regulatory machinery. miRNAs have seemingly paradoxical features: a single miRNA is able to simultaneously target hundreds of genes, while its presence is mostly dispensable for animal viability under normal conditions. It is known that miRNAs act as stress response factors; however, it remains challenging to determine their relevant targets and the conditions under which they function. To address this challenge, we propose a new workflow for miRNA function analysis, by which we found that the evolutionarily young miRNA family, the mir-310s (mir-310/mir-311/mir-312/mir-313), are important regulators of Drosophila metabolic status. mir-310s-deficient animals have an abnormal diet-dependent expression profile for numerous diet-sensitive components, accumulate fats, and show various physiological defects. We found that the mir-310s simultaneously repress the production of several regulatory factors (Rab23, DHR96, and Ttk) of the evolutionarily conserved Hedgehog (Hh) pathway to sharpen dietary response. As the mir-310s expression is highly dynamic and nutrition sensitive, this signal relay model helps to explain the molecular mechanism governing quick and robust Hh signaling responses to nutritional changes. Additionally, we discovered a new component of the Hh signaling pathway in Drosophila, Rab23, which cell autonomously regulates Hh ligand trafficking in the germline stem cell niche. How organisms adjust to dietary fluctuations to sustain healthy homeostasis is an intriguing research topic. These data are the first to report that miRNAs can act as executives that transduce nutritional signals to an essential signaling pathway. This suggests miRNAs as plausible therapeutic agents that can be used in combination with low calorie and cholesterol diets to manage quick and precise tissue-specific responses to nutritional changes." @default.
• W2296222259 created "2016-06-24" @default.
• W2296222259 creator A5009859857 @default.
• W2296222259 creator A5026069642 @default.
• W2296222259 creator A5066187407 @default.
• W2296222259 creator A5075083459 @default.
• W2296222259 creator A5081236786 @default.
• W2296222259 creator A5089006758 @default.
• W2296222259 date "2016-01-22" @default.
• W2296222259 modified "2023-10-16" @default.
• W2296222259 title "Hedgehog Signaling Strength Is Orchestrated by the <i>mir-310</i> Cluster of MicroRNAs in Response to Diet" @default.
• W2296222259 cites W1532026954 @default.
• W2296222259 cites W1535885360 @default.
• W2296222259 cites W1595083713 @default.
• W2296222259 cites W1679992491 @default.
• W2296222259 cites W1825701914 @default.
• W2296222259 cites W1953434579 @default.
• W2296222259 cites W1965462333 @default.
• W2296222259 cites W1968631483 @default.
• W2296222259 cites W1968931484 @default.
• W2296222259 cites W1969832749 @default.
• W2296222259 cites W1975662382 @default.
• W2296222259 cites W1977203585 @default.
• W2296222259 cites W1978489579 @default.
• W2296222259 cites W1980808407 @default.
• W2296222259 cites W1980997274 @default.
• W2296222259 cites W1982726261 @default.
• W2296222259 cites W1988863334 @default.
• W2296222259 cites W1992935306 @default.
• W2296222259 cites W2007594132 @default.
• W2296222259 cites W2010402064 @default.
• W2296222259 cites W2012932067 @default.
• W2296222259 cites W2014137007 @default.
• W2296222259 cites W2015284016 @default.
• W2296222259 cites W2017718158 @default.
• W2296222259 cites W2020154252 @default.
• W2296222259 cites W2020501644 @default.
• W2296222259 cites W2022027427 @default.
• W2296222259 cites W2025567758 @default.
• W2296222259 cites W2026412213 @default.
• W2296222259 cites W2027862889 @default.
• W2296222259 cites W2029042594 @default.
• W2296222259 cites W2036959083 @default.
• W2296222259 cites W2044283072 @default.
• W2296222259 cites W2044832480 @default.
• W2296222259 cites W2049117537 @default.
• W2296222259 cites W2057697250 @default.
• W2296222259 cites W2067174710 @default.
• W2296222259 cites W2070593887 @default.
• W2296222259 cites W2073397397 @default.
• W2296222259 cites W2077904579 @default.
• W2296222259 cites W2082356432 @default.
• W2296222259 cites W2094516974 @default.
• W2296222259 cites W2102216585 @default.
• W2296222259 cites W2105241495 @default.
• W2296222259 cites W2105651273 @default.
• W2296222259 cites W2105924489 @default.
• W2296222259 cites W2107136491 @default.
• W2296222259 cites W2112399708 @default.
• W2296222259 cites W2114383470 @default.
• W2296222259 cites W2115629461 @default.
• W2296222259 cites W2120456037 @default.
• W2296222259 cites W2125459905 @default.
• W2296222259 cites W2130657728 @default.
• W2296222259 cites W2139985100 @default.
• W2296222259 cites W2140439418 @default.
• W2296222259 cites W2140962206 @default.
• W2296222259 cites W2145152682 @default.
• W2296222259 cites W2146264786 @default.
• W2296222259 cites W2146548905 @default.
• W2296222259 cites W2147044753 @default.
• W2296222259 cites W2147662987 @default.
• W2296222259 cites W2148183327 @default.
• W2296222259 cites W2153551557 @default.
• W2296222259 cites W2157106732 @default.
• W2296222259 cites W2164991328 @default.
• W2296222259 cites W2166243815 @default.
• W2296222259 cites W2166894044 @default.
• W2296222259 cites W2167099568 @default.
• W2296222259 cites W2167179274 @default.
• W2296222259 cites W2168132477 @default.
• W2296222259 cites W2207345272 @default.
• W2296222259 cites W2605068739 @default.
• W2296222259 doi "https://doi.org/10.1534/genetics.115.185371" @default.
• W2296222259 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4788116" @default.
• W2296222259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26801178" @default.
• W2296222259 hasPublicationYear "2016" @default.
• W2296222259 type Work @default.
• W2296222259 sameAs 2296222259 @default.
• W2296222259 citedByCount "31" @default.
• W2296222259 countsByYear W22962222592016 @default.
• W2296222259 countsByYear W22962222592017 @default.
• W2296222259 countsByYear W22962222592018 @default.
• W2296222259 countsByYear W22962222592019 @default.
• W2296222259 countsByYear W22962222592020 @default.
• W2296222259 countsByYear W22962222592021 @default.
• W2296222259 countsByYear W22962222592022 @default.
• W2296222259 countsByYear W22962222592023 @default.

• next