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- W2296233075 abstract "Abstract Aims Natural killer (NK) cells play critical roles in antitumor immunity. Our previous study showed that over-expression of miR-30c-1* enhanced NKL cell cytotoxicity through up-regulation of tumor necrosis factor-α via directly targeting transcription factor homeobox containing 1. MiR-30c, the complimentary microRNA of miR-30c-1*, has been found to exert regulatory effect on T cell function. However, the effect of miR-30c on NK cells is unknown. Therefore, this study aimed to investigate whether miR-30c could play a role to enhance NK cell activation and cytotoxicity. Main methods Chemosynthesis exogenous miR-30c mimics and miR-30c inhibitor were transfected into NKL cells and isolated human peripheral blood NK cells, respectively. The expression levels of NK group 2, member D (NKG2D), CD107a and FasL on cell surface and cytotoxic ability of miRNAs transfected NKL cells against SMMC-7721 cells were evaluated. Key findings MiR-30c could increase the expression of NKG2D and CD107a on NKL cells, and enhance cytotoxic ability of NKL cells to kill SMMC-7721 cells. Moreover, miR-30c could up-regulate the expression of FasL on both NKL cells and human peripheral blood NK cells. However, the peripheral blood NK cells from only four in ten healthy donors appeared high expression levels of NKG2D and CD107a after miR-30c transfection. Significance MiR-30c could promote the cytotoxicity of NKL cells in vitro by up-regulating the expression levels of NKG2D, CD107a and FasL. However, the effect of miR-30c on ex vivo NK cells from different human individuals is diverse, indicating that miR-30c may play complicate and fine adjustment in immune system." @default.
- W2296233075 created "2016-06-24" @default.
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- W2296233075 date "2016-04-01" @default.
- W2296233075 modified "2023-10-10" @default.
- W2296233075 title "MicroRNA-30c promotes natural killer cell cytotoxicity via up-regulating the expression level of NKG2D" @default.
- W2296233075 cites W1481809543 @default.
- W2296233075 cites W1594374168 @default.
- W2296233075 cites W1788266451 @default.
- W2296233075 cites W1852572532 @default.
- W2296233075 cites W1945007132 @default.
- W2296233075 cites W1951934566 @default.
- W2296233075 cites W1954862601 @default.
- W2296233075 cites W1966054625 @default.
- W2296233075 cites W1970772565 @default.
- W2296233075 cites W1973909437 @default.
- W2296233075 cites W1976029219 @default.
- W2296233075 cites W1977745306 @default.
- W2296233075 cites W1980924310 @default.
- W2296233075 cites W1981352048 @default.
- W2296233075 cites W1985645275 @default.
- W2296233075 cites W1985685212 @default.
- W2296233075 cites W1986118460 @default.
- W2296233075 cites W1992420760 @default.
- W2296233075 cites W1994246752 @default.
- W2296233075 cites W1994279450 @default.
- W2296233075 cites W1998142094 @default.
- W2296233075 cites W1998888714 @default.
- W2296233075 cites W2004101061 @default.
- W2296233075 cites W2006073656 @default.
- W2296233075 cites W2007381960 @default.
- W2296233075 cites W2023336620 @default.
- W2296233075 cites W2025978850 @default.
- W2296233075 cites W2026884886 @default.
- W2296233075 cites W2027598316 @default.
- W2296233075 cites W2032114357 @default.
- W2296233075 cites W2044655073 @default.
- W2296233075 cites W2048238271 @default.
- W2296233075 cites W2050752994 @default.
- W2296233075 cites W2054327816 @default.
- W2296233075 cites W2055782750 @default.
- W2296233075 cites W2058197985 @default.
- W2296233075 cites W2069004357 @default.
- W2296233075 cites W2069357915 @default.
- W2296233075 cites W2074995508 @default.
- W2296233075 cites W2079870561 @default.
- W2296233075 cites W2080848323 @default.
- W2296233075 cites W2086424362 @default.
- W2296233075 cites W2093038807 @default.
- W2296233075 cites W2100324029 @default.
- W2296233075 cites W2113417184 @default.
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- W2296233075 cites W2125550288 @default.
- W2296233075 cites W2127944870 @default.
- W2296233075 cites W2128674168 @default.
- W2296233075 cites W2129621430 @default.
- W2296233075 cites W2142548447 @default.
- W2296233075 cites W2147735172 @default.
- W2296233075 cites W2149184686 @default.
- W2296233075 cites W2149784145 @default.
- W2296233075 cites W2159257250 @default.
- W2296233075 cites W2163956045 @default.
- W2296233075 cites W2174101211 @default.
- W2296233075 cites W2320539774 @default.
- W2296233075 cites W2321192620 @default.
- W2296233075 cites W4230564818 @default.
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- W2296233075 doi "https://doi.org/10.1016/j.lfs.2016.03.012" @default.
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