Matches in SemOpenAlex for { <https://semopenalex.org/work/W2296370458> ?p ?o ?g. }
- W2296370458 abstract "Aberrant neuregulin-1 (NRG1) signals are suggested to associate with the neuropathophysiology of schizophrenia. Employing a mouse schizophrenia model established by neonatal neuregulin-1 challenge, we analysed postpubertal consequence of the NRG1 pretreatment for the electrophysiological property of nigral dopamine neurons. In vivo single unit recordings from anaesthetized NRG1-pretreated mice revealed increased spike bursting of nigral dopamine neurons. In slice preparations from NRG1-pretreated mice, spontaneous firing was elevated relative to controls. The relative increase in firing rates was abolished by a GABAA receptor antagonist. Whole-cell recording showed that perinatal NRG1 pretreatment diminished inhibitory miniature synaptic currents as well as GABAA receptor sensitivity. These results collectively suggest that perinatal exposure to neuregulin-1 results in the disinhibition of nigral dopamine neurons to influence their firing properties at the adult stage when the behavioral deficits are evident." @default.
- W2296370458 created "2016-06-24" @default.
- W2296370458 creator A5047294260 @default.
- W2296370458 creator A5061069554 @default.
- W2296370458 creator A5087111105 @default.
- W2296370458 date "2016-03-03" @default.
- W2296370458 modified "2023-10-12" @default.
- W2296370458 title "Perinatal Exposure to Neuregulin-1 Results in Disinhibition of Adult Midbrain Dopaminergic Neurons: Implication in Schizophrenia Modeling" @default.
- W2296370458 cites W101525073 @default.
- W2296370458 cites W1583412938 @default.
- W2296370458 cites W1626809853 @default.
- W2296370458 cites W1633847368 @default.
- W2296370458 cites W1823302046 @default.
- W2296370458 cites W1912716570 @default.
- W2296370458 cites W1969121859 @default.
- W2296370458 cites W1971104810 @default.
- W2296370458 cites W1974737922 @default.
- W2296370458 cites W1980121446 @default.
- W2296370458 cites W1980737345 @default.
- W2296370458 cites W1985079872 @default.
- W2296370458 cites W1994984635 @default.
- W2296370458 cites W1998364591 @default.
- W2296370458 cites W2005643237 @default.
- W2296370458 cites W2009424285 @default.
- W2296370458 cites W2011599115 @default.
- W2296370458 cites W2014239075 @default.
- W2296370458 cites W2019892959 @default.
- W2296370458 cites W2023823207 @default.
- W2296370458 cites W2025747086 @default.
- W2296370458 cites W2031755128 @default.
- W2296370458 cites W2032301755 @default.
- W2296370458 cites W2034708714 @default.
- W2296370458 cites W2037051573 @default.
- W2296370458 cites W2041541520 @default.
- W2296370458 cites W2042335457 @default.
- W2296370458 cites W2043084931 @default.
- W2296370458 cites W2044265850 @default.
- W2296370458 cites W2050061925 @default.
- W2296370458 cites W2053941511 @default.
- W2296370458 cites W2065598132 @default.
- W2296370458 cites W2065932284 @default.
- W2296370458 cites W2071566065 @default.
- W2296370458 cites W2077932209 @default.
- W2296370458 cites W2093461705 @default.
- W2296370458 cites W2100068597 @default.
- W2296370458 cites W2108867507 @default.
- W2296370458 cites W2110034030 @default.
- W2296370458 cites W2110747461 @default.
- W2296370458 cites W2116774419 @default.
- W2296370458 cites W2125138207 @default.
- W2296370458 cites W2125705356 @default.
- W2296370458 cites W2129210738 @default.
- W2296370458 cites W2138220280 @default.
- W2296370458 cites W2143923065 @default.
- W2296370458 cites W2145602532 @default.
- W2296370458 cites W2145728950 @default.
- W2296370458 cites W2146291241 @default.
- W2296370458 cites W2146564511 @default.
- W2296370458 cites W2155801360 @default.
- W2296370458 cites W2157815289 @default.
- W2296370458 cites W2162579782 @default.
- W2296370458 cites W2169167644 @default.
- W2296370458 cites W2171601942 @default.
- W2296370458 cites W2414430852 @default.
- W2296370458 cites W2241719354 @default.
- W2296370458 doi "https://doi.org/10.1038/srep22606" @default.
- W2296370458 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4776181" @default.
- W2296370458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26935991" @default.
- W2296370458 hasPublicationYear "2016" @default.
- W2296370458 type Work @default.
- W2296370458 sameAs 2296370458 @default.
- W2296370458 citedByCount "12" @default.
- W2296370458 countsByYear W22963704582017 @default.
- W2296370458 countsByYear W22963704582018 @default.
- W2296370458 countsByYear W22963704582019 @default.
- W2296370458 countsByYear W22963704582020 @default.
- W2296370458 countsByYear W22963704582022 @default.
- W2296370458 countsByYear W22963704582023 @default.
- W2296370458 crossrefType "journal-article" @default.
- W2296370458 hasAuthorship W2296370458A5047294260 @default.
- W2296370458 hasAuthorship W2296370458A5061069554 @default.
- W2296370458 hasAuthorship W2296370458A5087111105 @default.
- W2296370458 hasBestOaLocation W22963704581 @default.
- W2296370458 hasConcept C118552586 @default.
- W2296370458 hasConcept C126322002 @default.
- W2296370458 hasConcept C137183658 @default.
- W2296370458 hasConcept C168258287 @default.
- W2296370458 hasConcept C169760540 @default.
- W2296370458 hasConcept C170493617 @default.
- W2296370458 hasConcept C17077164 @default.
- W2296370458 hasConcept C185263204 @default.
- W2296370458 hasConcept C195221683 @default.
- W2296370458 hasConcept C2776412080 @default.
- W2296370458 hasConcept C2776512019 @default.
- W2296370458 hasConcept C2776599063 @default.
- W2296370458 hasConcept C2778560701 @default.
- W2296370458 hasConcept C2779263132 @default.
- W2296370458 hasConcept C513476851 @default.
- W2296370458 hasConcept C529278444 @default.
- W2296370458 hasConcept C552161191 @default.