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- W2296386213 abstract "Background and purpose: The effects of long-term smoking on mitochondrial DNA (mtDNA) deletions in hair follicles were investigated in subjects with different thiol-related antioxidant capacities. Methods: Twenty-two male smokers with a smoking index of greater than 5 pack-years and without any known systemic diseases were recruited for this study. Forty healthy males without smoking history were also included as control subjects. Thio-related antioxidants in plasma and a 4,977-bp segment of deleted mtDNA (dmtDNA) in the hair follicle were tested in all subjects. Results: The activities of glutathione S-transferase (GST) and glutathione peroxidase in blood plasma were significantly decreased in smokers. The levels of glutathione and protein thiols in whole blood and the incidence of a 4,977-bp dmtDNA were significantly increased in smokers. A significantly higher incidence of the 4,977-bp dmtDNA was found in smokers with plasma GST activity less than 5.66 U/L (OR=7.2, P=.020). By using a multi-covariate analysis of variance (ANOVA) and logistic regression, we found that age and low plasma GST activity were the only two risk factors causing the 4,977-bp dmtDNA. Conclusion: These results suggest that smoking depletes antioxidants and causes mtDNA deletions and that plasma GST may play an important role in the preservation of mitochondrial genome in the somatic cells of smokers." @default.
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- W2296386213 date "2002-10-01" @default.
- W2296386213 modified "2023-09-25" @default.
- W2296386213 title "Alterations of Plasma thiol-related Antioxidants and Mitochondrial DNA Mutation in Hair Follicles of Smokers" @default.
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