FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2296402508> ?p ?o ?g. }

• W2296402508 endingPage "7" @default.
• W2296402508 startingPage "1" @default.
• W2296402508 abstract "Synaptic plasticity refers to the ability of neurons to strengthen or weaken synaptic efficacy in response to activity and is the basis for learning and memory. Glial cells communicate with neurons and in this way contribute in part to plasticity in the CNS and to the pathology of Alzheimer’s disease (AD), a neurodegenerative disease in which impaired synaptic plasticity is causally implicated. The transient receptor potential melastatin member 2 (TRPM2) channel is a nonselective Ca 2+ -permeable channel expressed in both glial cells (microglia and astrocytes) and neurons. Recent studies indicated that TRPM2 regulates synaptic plasticity as well as the activation of glial cells. TRPM2 also modulates oxidative stress and inflammation through interaction with glial cells. As both oxidative stress and inflammation have been implicated in AD pathology, this suggests a possible contribution of TRPM2 to disease processes. Through modulating the homeostasis of glutathione, TRPM2 is involved in the process of aging which is a risk factor of AD. These results potentially point TRPM2 channel to be involved in AD through glial cells. This review summarizes recent advances in studying the contribution of TRPM2 in health and in AD pathology, with a focus on contributions via glia cells." @default.
• W2296402508 created "2016-06-24" @default.
• W2296402508 creator A5006034052 @default.
• W2296402508 creator A5037677450 @default.
• W2296402508 creator A5054493580 @default.
• W2296402508 date "2016-01-01" @default.
• W2296402508 modified "2023-10-14" @default.
• W2296402508 title "Glia and TRPM2 Channels in Plasticity of Central Nervous System and Alzheimer’s Diseases" @default.
• W2296402508 cites W112730390 @default.
• W2296402508 cites W1489975469 @default.
• W2296402508 cites W1533236567 @default.
• W2296402508 cites W1706853038 @default.
• W2296402508 cites W1876773427 @default.
• W2296402508 cites W1968024448 @default.
• W2296402508 cites W1971276386 @default.
• W2296402508 cites W1972085322 @default.
• W2296402508 cites W1973225398 @default.
• W2296402508 cites W1976116790 @default.
• W2296402508 cites W1978727902 @default.
• W2296402508 cites W1979791785 @default.
• W2296402508 cites W1982950563 @default.
• W2296402508 cites W1983247143 @default.
• W2296402508 cites W1984737099 @default.
• W2296402508 cites W1986354445 @default.
• W2296402508 cites W1988203397 @default.
• W2296402508 cites W1995521991 @default.
• W2296402508 cites W1996462430 @default.
• W2296402508 cites W1997319312 @default.
• W2296402508 cites W2000225222 @default.
• W2296402508 cites W2003931473 @default.
• W2296402508 cites W2009065017 @default.
• W2296402508 cites W2011656541 @default.
• W2296402508 cites W2013144126 @default.
• W2296402508 cites W2013971744 @default.
• W2296402508 cites W2019921978 @default.
• W2296402508 cites W2022047973 @default.
• W2296402508 cites W2030834682 @default.
• W2296402508 cites W2032089431 @default.
• W2296402508 cites W2032594368 @default.
• W2296402508 cites W2037132719 @default.
• W2296402508 cites W2041856584 @default.
• W2296402508 cites W2042726169 @default.
• W2296402508 cites W2048173148 @default.
• W2296402508 cites W2053260993 @default.
• W2296402508 cites W2053318380 @default.
• W2296402508 cites W2063863075 @default.
• W2296402508 cites W2064460242 @default.
• W2296402508 cites W2065685531 @default.
• W2296402508 cites W2074396059 @default.
• W2296402508 cites W2088284560 @default.
• W2296402508 cites W2096500024 @default.
• W2296402508 cites W2101371013 @default.
• W2296402508 cites W2102732075 @default.
• W2296402508 cites W2114324710 @default.
• W2296402508 cites W2139730325 @default.
• W2296402508 cites W2142063792 @default.
• W2296402508 cites W2143455491 @default.
• W2296402508 cites W2151640318 @default.
• W2296402508 cites W2155524482 @default.
• W2296402508 cites W2164558765 @default.
• W2296402508 cites W2180655326 @default.
• W2296402508 cites W2223781517 @default.
• W2296402508 cites W2310802833 @default.
• W2296402508 cites W88045577 @default.
• W2296402508 doi "https://doi.org/10.1155/2016/1680905" @default.
• W2296402508 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4749827" @default.
• W2296402508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26942016" @default.
• W2296402508 hasPublicationYear "2016" @default.
• W2296402508 type Work @default.
• W2296402508 sameAs 2296402508 @default.
• W2296402508 citedByCount "23" @default.
• W2296402508 countsByYear W22964025082016 @default.
• W2296402508 countsByYear W22964025082017 @default.
• W2296402508 countsByYear W22964025082018 @default.
• W2296402508 countsByYear W22964025082019 @default.
• W2296402508 countsByYear W22964025082020 @default.
• W2296402508 countsByYear W22964025082021 @default.
• W2296402508 countsByYear W22964025082022 @default.
• W2296402508 crossrefType "journal-article" @default.
• W2296402508 hasAuthorship W2296402508A5006034052 @default.
• W2296402508 hasAuthorship W2296402508A5037677450 @default.
• W2296402508 hasAuthorship W2296402508A5054493580 @default.
• W2296402508 hasBestOaLocation W22964025081 @default.
• W2296402508 hasConcept C134018914 @default.
• W2296402508 hasConcept C151495721 @default.
• W2296402508 hasConcept C155164980 @default.
• W2296402508 hasConcept C169760540 @default.
• W2296402508 hasConcept C170493617 @default.
• W2296402508 hasConcept C203014093 @default.
• W2296402508 hasConcept C2776151105 @default.
• W2296402508 hasConcept C2776914184 @default.
• W2296402508 hasConcept C2779830541 @default.
• W2296402508 hasConcept C47611674 @default.
• W2296402508 hasConcept C55493867 @default.
• W2296402508 hasConcept C86803240 @default.
• W2296402508 hasConcept C98229152 @default.
• W2296402508 hasConceptScore W2296402508C134018914 @default.
• W2296402508 hasConceptScore W2296402508C151495721 @default.

• next