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- W2296408775 endingPage "e0151147" @default.
- W2296408775 startingPage "e0151147" @default.
- W2296408775 abstract "Decline of cognitive function is the hallmark of Alzheimer's disease (AD), regardless of the pathological mechanism. Traditional Chinese medicine has been used to combat cognitive impairments and has been shown to improve learning and memory. Radix Polygalae (RAPO) is a typical and widely used herbal medicine. In this study, we aimed to follow the β-amyloid (Aβ) reduction activity to identify active constituent(s) of RAPO. We found that Onjisaponin B of RAPO functioned as RAPO to suppress Aβ production without direct inhibition of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and γ-secretase activities. Our mechanistic study showed that Onjisaponin B promoted the degradation of amyloid precursor protein (APP). Further, oral administration of Onjisaponin B ameliorated Aβ pathology and behavioral defects in APP/PS1 mice. Taken together, our results indicate that Onjisaponin B is effective against AD, providing a new therapeutic agent for further drug discovery." @default.
- W2296408775 created "2016-06-24" @default.
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- W2296408775 date "2016-03-08" @default.
- W2296408775 modified "2023-10-06" @default.
- W2296408775 title "Traditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive Impairments" @default.
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- W2296408775 doi "https://doi.org/10.1371/journal.pone.0151147" @default.
- W2296408775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4782990" @default.
- W2296408775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26954017" @default.
- W2296408775 hasPublicationYear "2016" @default.
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