FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2296479342> ?p ?o ?g. }

• W2296479342 endingPage "206" @default.
• W2296479342 startingPage "194" @default.
• W2296479342 abstract "Background: Asthma is a complex and heterogeneous chronic inflammatory disorder which is characterized by airway remodeling and airway inflammation, including goblet cell and airway smooth muscle cell hyperplasia, mucus hypersecretion and eosinophils infiltration. Epidermal growth factor receptor (EGFR) plays an important role in goblet cell hyperplasia and mucus hypersecretion. We aimed to investigate the effects of gefitinib, an EGFR inhibitor, on ovalbumin (OVA)-induced airway remodeling and inflammation of a mouse model of asthma. Methods: Pathological changes of OVA sensitization of BALB/c mice were measured by H&E and PAS staining; pEGFR, Bcl-2 and Bax expression was measured by western blot; ELISA was used to measure the level of muc5ac, IL-13 and IFN-γ; TUNEL staining was used to detect goblet cell apoptosis. Results: At the present study, H&E and PAS staining showed that mice pretreated with gefinitib developed fewer pathological changes compared with asthmatic mice and gefinitib treatment asthmatic mice, such as a remarkable reduction in airway inflammation, goblet cell and airway smooth muscle cell hyperplasia. Chronic gefitinib treatment or short-term gefitinib treatment significant down-regulate the expression of pEGFR compared with asthma group. Also, chronic gefitinib treatment markedly decreased the levels of muc5ac and IL-13 in BALF, whereas the level of IFN-γ did not change obviously. TUNEL staining showed that the goblet cell apoptosis rate was much higher in the short-term gefinitib treatment group compared with the asthma and chronic gefitinib treatment group which was accompanied by a decrease in Bcl-2 levels and an increase in Bax expression in goblet cells. Conclusion: In summary, our results suggested that gefinitib may have a potential role in airway remodeling and inflammation, and may be an effective pharmacotherapy for asthma." @default.
• W2296479342 created "2016-06-24" @default.
• W2296479342 creator A5023056600 @default.
• W2296479342 creator A5033631000 @default.
• W2296479342 creator A5040454155 @default.
• W2296479342 creator A5044826890 @default.
• W2296479342 creator A5045951720 @default.
• W2296479342 creator A5051497416 @default.
• W2296479342 creator A5076036088 @default.
• W2296479342 date "2016-01-01" @default.
• W2296479342 modified "2023-10-18" @default.
• W2296479342 title "The Chronic and Short-Term Effects of Gefinitib on Airway Remodeling and Inflammation in a Mouse Model of Asthma" @default.
• W2296479342 cites W1552210756 @default.
• W2296479342 cites W1856138154 @default.
• W2296479342 cites W1914905501 @default.
• W2296479342 cites W1947221834 @default.
• W2296479342 cites W1967072649 @default.
• W2296479342 cites W1968431199 @default.
• W2296479342 cites W1968510262 @default.
• W2296479342 cites W1976238796 @default.
• W2296479342 cites W1980597708 @default.
• W2296479342 cites W1989823894 @default.
• W2296479342 cites W2000368187 @default.
• W2296479342 cites W2001186089 @default.
• W2296479342 cites W2007528734 @default.
• W2296479342 cites W2026110267 @default.
• W2296479342 cites W2028878799 @default.
• W2296479342 cites W2036974395 @default.
• W2296479342 cites W2043066069 @default.
• W2296479342 cites W2043990114 @default.
• W2296479342 cites W2045585687 @default.
• W2296479342 cites W2048820943 @default.
• W2296479342 cites W2049274590 @default.
• W2296479342 cites W2049648341 @default.
• W2296479342 cites W2051120695 @default.
• W2296479342 cites W2057380855 @default.
• W2296479342 cites W2065149104 @default.
• W2296479342 cites W2066355521 @default.
• W2296479342 cites W2068414464 @default.
• W2296479342 cites W2073310243 @default.
• W2296479342 cites W2082427057 @default.
• W2296479342 cites W2103681608 @default.
• W2296479342 cites W2106610863 @default.
• W2296479342 cites W2113993188 @default.
• W2296479342 cites W2116932347 @default.
• W2296479342 cites W2117966309 @default.
• W2296479342 cites W2120184224 @default.
• W2296479342 cites W2120374931 @default.
• W2296479342 cites W2135555439 @default.
• W2296479342 cites W2152164517 @default.
• W2296479342 cites W2156727738 @default.
• W2296479342 cites W2161641464 @default.
• W2296479342 cites W2164692566 @default.
• W2296479342 cites W2166881631 @default.
• W2296479342 cites W2167368130 @default.
• W2296479342 cites W2185209554 @default.
• W2296479342 cites W2412682954 @default.
• W2296479342 cites W2182797274 @default.
• W2296479342 doi "https://doi.org/10.1159/000438621" @default.
• W2296479342 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26784930" @default.
• W2296479342 hasPublicationYear "2016" @default.
• W2296479342 type Work @default.
• W2296479342 sameAs 2296479342 @default.
• W2296479342 citedByCount "16" @default.
• W2296479342 countsByYear W22964793422017 @default.
• W2296479342 countsByYear W22964793422018 @default.
• W2296479342 countsByYear W22964793422019 @default.
• W2296479342 countsByYear W22964793422020 @default.
• W2296479342 countsByYear W22964793422021 @default.
• W2296479342 crossrefType "journal-article" @default.
• W2296479342 hasAuthorship W2296479342A5023056600 @default.
• W2296479342 hasAuthorship W2296479342A5033631000 @default.
• W2296479342 hasAuthorship W2296479342A5040454155 @default.
• W2296479342 hasAuthorship W2296479342A5044826890 @default.
• W2296479342 hasAuthorship W2296479342A5045951720 @default.
• W2296479342 hasAuthorship W2296479342A5051497416 @default.
• W2296479342 hasAuthorship W2296479342A5076036088 @default.
• W2296479342 hasBestOaLocation W22964793421 @default.
• W2296479342 hasConcept C126322002 @default.
• W2296479342 hasConcept C142724271 @default.
• W2296479342 hasConcept C170493617 @default.
• W2296479342 hasConcept C18903297 @default.
• W2296479342 hasConcept C190283241 @default.
• W2296479342 hasConcept C196795494 @default.
• W2296479342 hasConcept C203014093 @default.
• W2296479342 hasConcept C204232928 @default.
• W2296479342 hasConcept C2775941134 @default.
• W2296479342 hasConcept C2776914184 @default.
• W2296479342 hasConcept C2776946954 @default.
• W2296479342 hasConcept C2777312293 @default.
• W2296479342 hasConcept C2777562237 @default.
• W2296479342 hasConcept C2779438470 @default.
• W2296479342 hasConcept C2780580887 @default.
• W2296479342 hasConcept C529295009 @default.
• W2296479342 hasConcept C55493867 @default.
• W2296479342 hasConcept C71924100 @default.
• W2296479342 hasConcept C86803240 @default.
• W2296479342 hasConcept C8891405 @default.

• next