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• W2296594992 abstract "In the vertebrate neural tube, a morphogen-induced transcriptional network produces multiple molecularly distinct progenitor domains, each generating different neuronal subtypes. Using an in vitro differentiation system, we defined gene expression signatures of distinct progenitor populations and identified direct gene-regulatory inputs corresponding to locations of specific transcription factor binding. Combined with targeted perturbations of the network, this revealed a mechanism in which a progenitor identity is installed by active repression of the entire transcriptional programs of other neural progenitor fates. In the ventral neural tube, sonic hedgehog (Shh) signaling, together with broadly expressed transcriptional activators, concurrently activates the gene expression programs of several domains. The specific outcome is selected by repressive input provided by Shh-induced transcription factors that act as the key nodes in the network, enabling progenitors to adopt a single definitive identity from several initially permitted options. Together, the data suggest design principles relevant to many developing tissues." @default.
• W2296594992 created "2016-06-24" @default.
• W2296594992 creator A5007978997 @default.
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• W2296594992 date "2016-03-01" @default.
• W2296594992 modified "2023-10-13" @default.
• W2296594992 title "Neural Progenitors Adopt Specific Identities by Directly Repressing All Alternative Progenitor Transcriptional Programs" @default.
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• W2296594992 doi "https://doi.org/10.1016/j.devcel.2016.02.013" @default.
• W2296594992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4819439" @default.
• W2296594992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26972603" @default.
• W2296594992 hasPublicationYear "2016" @default.
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