FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2296605000> ?p ?o ?g. }

• W2296605000 endingPage "144" @default.
• W2296605000 startingPage "135" @default.
• W2296605000 abstract "<b><i>Background/Aims:</i></b> Data from a considerable number of malignancies demonstrate that depletion of the essential amino acid tryptophan via induction of the immunoregulatory enzyme indoleamine-2,3-dioxygenase (IDO) serves as an important tumour escape strategy and is of prognostic importance. Here we investigate the predictive value of the activity of IDO as well as levels of tryptophan and respective downstream catabolites in a large cohort of patients with neuroendocrine neoplasms (NEN). <b><i>Methods:</i></b> 142 consecutive Caucasian patients (62 male, aged 60.3 ± 11.9 years) with histologically confirmed NEN were systematically analysed in a retrospective blinded end point analysis. Patients were followed up for a mean period of about 3.9 ± 1.9 years. Clinical outcome, levels of established biomarkers, and tryptophan degradation markers (assessed using tandem mass spectrometry) including estimated IDO activity were recorded. Cox proportional hazards regression models were performed for the assessment of prognostic power. <b><i>Results:</i></b> We found that baseline tryptophan levels were significantly lower and IDO activity was significantly increased in non-survivors. The risk for death inclined stepwise and was highest in patients in the upper tertile of IDO activity. Cox proportional regression models identified IDO activity as an independent predictor of death. <b><i>Conclusions:</i></b> In this retrospective analysis, we observed that baseline activity of the immunoregulatory enzyme IDO was significantly increased in non-survivors. IDO activity was identified as an independent predictor of death in this cohort of NEN patients. Whether IDO activity or tryptophan depletion serves to guide future therapeutic interventions in NEN remains to be established." @default.
• W2296605000 created "2016-06-24" @default.
• W2296605000 creator A5007891817 @default.
• W2296605000 creator A5034786208 @default.
• W2296605000 creator A5040211059 @default.
• W2296605000 creator A5042249311 @default.
• W2296605000 creator A5042553930 @default.
• W2296605000 creator A5046696433 @default.
• W2296605000 creator A5048652672 @default.
• W2296605000 creator A5054417922 @default.
• W2296605000 creator A5055143638 @default.
• W2296605000 creator A5061479895 @default.
• W2296605000 creator A5085147181 @default.
• W2296605000 date "2016-03-09" @default.
• W2296605000 modified "2023-10-02" @default.
• W2296605000 title "Increased Activity of the Immunoregulatory Enzyme Indoleamine-2,3-Dioxygenase with Consecutive Tryptophan Depletion Predicts Death in Patients with Neuroendocrine Neoplasia" @default.
• W2296605000 cites W1973251492 @default.
• W2296605000 cites W1975686877 @default.
• W2296605000 cites W1977067570 @default.
• W2296605000 cites W1984484036 @default.
• W2296605000 cites W1987171603 @default.
• W2296605000 cites W1987288591 @default.
• W2296605000 cites W1990509102 @default.
• W2296605000 cites W1994235502 @default.
• W2296605000 cites W1999601075 @default.
• W2296605000 cites W2003241000 @default.
• W2296605000 cites W2005429053 @default.
• W2296605000 cites W2010378562 @default.
• W2296605000 cites W2013139214 @default.
• W2296605000 cites W2032620235 @default.
• W2296605000 cites W2035078651 @default.
• W2296605000 cites W2038681512 @default.
• W2296605000 cites W2039437440 @default.
• W2296605000 cites W2042200211 @default.
• W2296605000 cites W2042985653 @default.
• W2296605000 cites W2066768964 @default.
• W2296605000 cites W2067540228 @default.
• W2296605000 cites W2070311659 @default.
• W2296605000 cites W2072078248 @default.
• W2296605000 cites W2079515425 @default.
• W2296605000 cites W2082434235 @default.
• W2296605000 cites W2090410108 @default.
• W2296605000 cites W2094530868 @default.
• W2296605000 cites W2096891166 @default.
• W2296605000 cites W2097156202 @default.
• W2296605000 cites W2104065243 @default.
• W2296605000 cites W2109207751 @default.
• W2296605000 cites W2109505011 @default.
• W2296605000 cites W2113153081 @default.
• W2296605000 cites W2113657892 @default.
• W2296605000 cites W2121902324 @default.
• W2296605000 cites W2122062731 @default.
• W2296605000 cites W2126932404 @default.
• W2296605000 cites W2127468351 @default.
• W2296605000 cites W2146914242 @default.
• W2296605000 cites W2149214723 @default.
• W2296605000 cites W2171437874 @default.
• W2296605000 cites W2172799097 @default.
• W2296605000 cites W2320075299 @default.
• W2296605000 cites W2339431931 @default.
• W2296605000 doi "https://doi.org/10.1159/000445191" @default.
• W2296605000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26954941" @default.
• W2296605000 hasPublicationYear "2016" @default.
• W2296605000 type Work @default.
• W2296605000 sameAs 2296605000 @default.
• W2296605000 citedByCount "4" @default.
• W2296605000 countsByYear W22966050002016 @default.
• W2296605000 countsByYear W22966050002018 @default.
• W2296605000 countsByYear W22966050002021 @default.
• W2296605000 countsByYear W22966050002022 @default.
• W2296605000 crossrefType "journal-article" @default.
• W2296605000 hasAuthorship W2296605000A5007891817 @default.
• W2296605000 hasAuthorship W2296605000A5034786208 @default.
• W2296605000 hasAuthorship W2296605000A5040211059 @default.
• W2296605000 hasAuthorship W2296605000A5042249311 @default.
• W2296605000 hasAuthorship W2296605000A5042553930 @default.
• W2296605000 hasAuthorship W2296605000A5046696433 @default.
• W2296605000 hasAuthorship W2296605000A5048652672 @default.
• W2296605000 hasAuthorship W2296605000A5054417922 @default.
• W2296605000 hasAuthorship W2296605000A5055143638 @default.
• W2296605000 hasAuthorship W2296605000A5061479895 @default.
• W2296605000 hasAuthorship W2296605000A5085147181 @default.
• W2296605000 hasBestOaLocation W22966050002 @default.
• W2296605000 hasConcept C126322002 @default.
• W2296605000 hasConcept C134018914 @default.
• W2296605000 hasConcept C167135981 @default.
• W2296605000 hasConcept C2776706248 @default.
• W2296605000 hasConcept C2777503454 @default.
• W2296605000 hasConcept C50382708 @default.
• W2296605000 hasConcept C515207424 @default.
• W2296605000 hasConcept C55493867 @default.
• W2296605000 hasConcept C71924100 @default.
• W2296605000 hasConcept C72563966 @default.
• W2296605000 hasConcept C83478079 @default.
• W2296605000 hasConcept C86803240 @default.
• W2296605000 hasConcept C90924648 @default.
• W2296605000 hasConceptScore W2296605000C126322002 @default.
• W2296605000 hasConceptScore W2296605000C134018914 @default.

• next