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- W2296606837 abstract "Genetic alterations which impair the function of the TP53 signaling pathway in TP53 wild-type human tumors remain elusive. To identify new components of this pathway, we performed a screen for genes whose loss-of-function debilitated TP53 signaling and enabled oncogenic transformation of human mammary epithelial cells. We identified transglutaminase 2 (TGM2) as a putative tumor suppressor in the TP53 pathway. TGM2 suppressed colony formation in soft agar and tumor formation in a xenograft mouse model. The depletion of growth supplements induced both TGM2 expression and autophagy in a TP53-dependent manner, and TGM2 promoted autophagic flux by enhancing autophagic protein degradation and autolysosome clearance. Reduced expression of both CDKN1A , which regulates the cell cycle downstream of TP53, and TGM2 synergized to promote oncogenic transformation. Our findings suggest that TGM2-mediated autophagy and CDKN1A-mediated cell cycle arrest are two important barriers in the TP53 pathway that prevent oncogenic transformation." @default.
- W2296606837 created "2016-06-24" @default.
- W2296606837 creator A5004339230 @default.
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- W2296606837 creator A5039870917 @default.
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- W2296606837 creator A5050300123 @default.
- W2296606837 creator A5057957774 @default.
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- W2296606837 creator A5082356558 @default.
- W2296606837 creator A5090916847 @default.
- W2296606837 creator A5091560850 @default.
- W2296606837 date "2016-03-09" @default.
- W2296606837 modified "2023-09-30" @default.
- W2296606837 title "Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation" @default.
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