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- W2296625472 abstract "Early diagnosis and effective treatment of bacterial infection has become increasingly important. Herein, we developed a fluorescent nano-probe MPA@ZnO-PEP by conjugating SiO2-stabilized ZnO quantum dot (ZnO@SiO2) with bacteria-targeting peptide PEP, which was encapsulated with MPA, a near infrared (NIR) dye. The nanoprobe MPA@ZnO-PEP showed excellent fluorescence property and could specifically distinguish bacterial infection from sterile inflammation both in vitro and in vivo. The favorable biocompatability of MPA@ZnO-PEP was verified by MTT assay. This probe was further modified with antibiotic methicillin to form the theranostic nanoparticle MPA/Met@ZnO-PEP with amplified antibacterial activity. These results promised the great potential of MPA@ZnO-PEP for efficient non-invasive early diagnosis of bacterial infections and effective bacterial-targeting therapy." @default.
- W2296625472 created "2016-06-24" @default.
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- W2296625472 date "2016-04-22" @default.
- W2296625472 modified "2023-09-23" @default.
- W2296625472 title "High specificity ZnO quantum dots for diagnosis and treatment in bacterial infection" @default.
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- W2296625472 doi "https://doi.org/10.1117/12.2220034" @default.
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