Matches in SemOpenAlex for { <https://semopenalex.org/work/W2296648384> ?p ?o ?g. }
- W2296648384 endingPage "081203" @default.
- W2296648384 startingPage "081203" @default.
- W2296648384 abstract "The developed optical clearing methods show great potential for imaging of large-volume tissues, but these methods present some nonnegligible limitations such as complexity of implementation and long incubation times. In this study, we tried to screen out rapid optical clearing agents by means of molecular dynamical simulation and experimental demonstration. According to the optical clearing potential of sugar and sugar-alcohol, we further evaluated the improvement in the optical clearing efficacy of mouse brain samples, imaging depth, fluorescence preservation, and linear deformation. The results showed that drops of sorbitol, sucrose, and fructose could quickly make the mouse brain sample transparent within 1 to 2 min, and induce about threefold enhancement in imaging depth. The former two could evidently enhance the fluorescence intensity of green fluorescent protein (GFP) and prodium iodide (PI) nuclear dye. Fructose could significantly increase the fluorescence intensity of PI, but slightly decrease the fluorescence intensity of GFP. Even though the three agents caused some shrinkage in samples, the contraction in horizontal and longitudinal directions are almost the same." @default.
- W2296648384 created "2016-06-24" @default.
- W2296648384 creator A5025933862 @default.
- W2296648384 creator A5045467934 @default.
- W2296648384 creator A5049818982 @default.
- W2296648384 creator A5051744476 @default.
- W2296648384 creator A5055341024 @default.
- W2296648384 creator A5056033605 @default.
- W2296648384 creator A5059286736 @default.
- W2296648384 creator A5067804978 @default.
- W2296648384 creator A5077930196 @default.
- W2296648384 creator A5090408728 @default.
- W2296648384 date "2016-03-11" @default.
- W2296648384 modified "2023-09-27" @default.
- W2296648384 title "Rapid and prodium iodide-compatible optical clearing method for brain tissue based on sugar/sugar-alcohol" @default.
- W2296648384 cites W1570588423 @default.
- W2296648384 cites W1964049834 @default.
- W2296648384 cites W1968634968 @default.
- W2296648384 cites W1972702281 @default.
- W2296648384 cites W1977490395 @default.
- W2296648384 cites W1978590690 @default.
- W2296648384 cites W1978658333 @default.
- W2296648384 cites W1997120927 @default.
- W2296648384 cites W2003025357 @default.
- W2296648384 cites W2004051393 @default.
- W2296648384 cites W2010114799 @default.
- W2296648384 cites W2010956007 @default.
- W2296648384 cites W2016277672 @default.
- W2296648384 cites W2017478274 @default.
- W2296648384 cites W2023601525 @default.
- W2296648384 cites W2029734814 @default.
- W2296648384 cites W2031832388 @default.
- W2296648384 cites W2032375852 @default.
- W2296648384 cites W2032714412 @default.
- W2296648384 cites W2047242615 @default.
- W2296648384 cites W2051036306 @default.
- W2296648384 cites W2051438014 @default.
- W2296648384 cites W2052003865 @default.
- W2296648384 cites W2054870083 @default.
- W2296648384 cites W2061125228 @default.
- W2296648384 cites W2072014991 @default.
- W2296648384 cites W2076507262 @default.
- W2296648384 cites W2078677652 @default.
- W2296648384 cites W2083048982 @default.
- W2296648384 cites W2087451538 @default.
- W2296648384 cites W2162859269 @default.
- W2296648384 cites W2167460696 @default.
- W2296648384 cites W2169118010 @default.
- W2296648384 cites W2208442878 @default.
- W2296648384 cites W2279851379 @default.
- W2296648384 cites W2287813283 @default.
- W2296648384 cites W3103749967 @default.
- W2296648384 cites W2189000902 @default.
- W2296648384 doi "https://doi.org/10.1117/1.jbo.21.8.081203" @default.
- W2296648384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26968577" @default.
- W2296648384 hasPublicationYear "2016" @default.
- W2296648384 type Work @default.
- W2296648384 sameAs 2296648384 @default.
- W2296648384 citedByCount "19" @default.
- W2296648384 countsByYear W22966483842016 @default.
- W2296648384 countsByYear W22966483842017 @default.
- W2296648384 countsByYear W22966483842018 @default.
- W2296648384 countsByYear W22966483842019 @default.
- W2296648384 countsByYear W22966483842020 @default.
- W2296648384 countsByYear W22966483842021 @default.
- W2296648384 countsByYear W22966483842022 @default.
- W2296648384 countsByYear W22966483842023 @default.
- W2296648384 crossrefType "journal-article" @default.
- W2296648384 hasAuthorship W2296648384A5025933862 @default.
- W2296648384 hasAuthorship W2296648384A5045467934 @default.
- W2296648384 hasAuthorship W2296648384A5049818982 @default.
- W2296648384 hasAuthorship W2296648384A5051744476 @default.
- W2296648384 hasAuthorship W2296648384A5055341024 @default.
- W2296648384 hasAuthorship W2296648384A5056033605 @default.
- W2296648384 hasAuthorship W2296648384A5059286736 @default.
- W2296648384 hasAuthorship W2296648384A5067804978 @default.
- W2296648384 hasAuthorship W2296648384A5077930196 @default.
- W2296648384 hasAuthorship W2296648384A5090408728 @default.
- W2296648384 hasBestOaLocation W22966483841 @default.
- W2296648384 hasConcept C104317684 @default.
- W2296648384 hasConcept C113976765 @default.
- W2296648384 hasConcept C120665830 @default.
- W2296648384 hasConcept C121332964 @default.
- W2296648384 hasConcept C12554922 @default.
- W2296648384 hasConcept C142613039 @default.
- W2296648384 hasConcept C169274487 @default.
- W2296648384 hasConcept C178790620 @default.
- W2296648384 hasConcept C185592680 @default.
- W2296648384 hasConcept C192562407 @default.
- W2296648384 hasConcept C2776779347 @default.
- W2296648384 hasConcept C2776970464 @default.
- W2296648384 hasConcept C2777108408 @default.
- W2296648384 hasConcept C2778597767 @default.
- W2296648384 hasConcept C2778870691 @default.
- W2296648384 hasConcept C55493867 @default.
- W2296648384 hasConcept C86803240 @default.
- W2296648384 hasConcept C91881484 @default.
- W2296648384 hasConceptScore W2296648384C104317684 @default.