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• W2296711894 endingPage "2844" @default.
• W2296711894 startingPage "2828" @default.
• W2296711894 abstract "Light is the major stimulus for the synchronization of circadian clocks with day-night cycles. The light-driven entrainment of the clock that controls rest-activity rhythms in Drosophila relies on different photoreceptive molecules. Cryptochrome (CRY) is expressed in most brain clock neurons, whereas six different rhodopsins (RH) are present in the light-sensing organs. The compound eye includes outer photoreceptors that express RH1 and inner photoreceptors that each express one of the four rhodopsins RH3-RH6. RH6 is also expressed in the extraretinal Hofbauer-Buchner eyelet, whereas RH2 is only found in the ocelli. In low light, the synchronization of behavioral rhythms relies on either CRY or the canonical rhodopsin phototransduction pathway, which requires the phospholipase C-β encoded by norpA (no receptor potential A). We used norpA(P24) cry(02) double mutants that are circadianly blind in low light and restored NORPA function in each of the six types of photoreceptors, defined as expressing a particular rhodopsin. We first show that the NORPA pathway is less efficient than CRY for synchronizing rest-activity rhythms with delayed light-dark cycles but is important for proper phasing, whereas the two light-sensing pathways can mediate efficient adjustments to phase advances. Four of the six rhodopsin-expressing photoreceptors can mediate circadian entrainment, and all are more efficient for advancing than for delaying the behavioral clock. In contrast, neither RH5-expressing retinal photoreceptors nor RH2-expressing ocellar photoreceptors are sufficient to mediate synchronization through the NORPA pathway. Our results thus reveal different contributions of rhodopsin-expressing photoreceptors and suggest the existence of several circuits for rhodopsin-dependent circadian entrainment. J. Comp. Neurol. 524:2828-2844, 2016. © 2016 Wiley Periodicals, Inc." @default.
• W2296711894 created "2016-06-24" @default.
• W2296711894 creator A5019499437 @default.
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• W2296711894 date "2016-03-28" @default.
• W2296711894 modified "2023-10-16" @default.
• W2296711894 title "Four of the six<i>Drosophila</i>rhodopsin-expressing photoreceptors can mediate circadian entrainment in low light" @default.
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• W2296711894 doi "https://doi.org/10.1002/cne.23994" @default.
• W2296711894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26972685" @default.
• W2296711894 hasPublicationYear "2016" @default.
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