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• W2296725125 abstract "Development of surface modification procedures which allow tuning the cell adhesion on the surface of biomaterials and devices is of great importance. In this study, the effects of different topographies and wettabilities on cell adhesion behavior of polymeric surfaces are investigated. To this end, an improved phase separation method was proposed to impart various wettabilities (hydrophobic and superhydrophobic) on polypropylene surfaces. Surface morphologies and compositions were characterized by scanning electron microscopy and X-ray photoelectron spectroscopy, respectively. Cell culture was conducted to evaluate the adhesion of 4T1 mouse mammary tumor cells. It was found that processing conditions such as drying temperature is highly influential in cell adhesion behavior due to the formation of an utterly different surface topography. It was concluded that surface topography plays a more significant role in cell adhesion behavior rather than superhydrophobicity since the nano-scale topography highly inhibited the cell adhesion as compared to the micro-scale topography. Such cell repellent behavior could be very useful in many biomedical devices such as those in drug delivery and blood contacting applications as well as biosensors." @default.
• W2296725125 created "2016-06-24" @default.
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• W2296725125 date "2016-06-01" @default.
• W2296725125 modified "2023-09-27" @default.
• W2296725125 title "Tuning cell adhesion on polymeric and nanocomposite surfaces: Role of topography versus superhydrophobicity" @default.
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• W2296725125 doi "https://doi.org/10.1016/j.msec.2016.03.021" @default.
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