FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2296740576> ?p ?o ?g. }

• W2296740576 endingPage "6611" @default.
• W2296740576 startingPage "6592" @default.
• W2296740576 abstract "Some new water soluble complexes [N,N'-bis{5-[(triphenyl phosphonium chloride)-methyl]salicylidine}-3,4-diaminopyridine] M(ii), which are formulated as nano-[Zn(5-CH2PPh3-3,4-salpyr)](ClO4)2 (), [Zn(5-CH2PPh3-3,4-salpyr)](ClO4)2 (), nano-[Ni(5-CH2PPh3-3,4-salpyr)](ClO4)2 (), [Ni(5-CH2PPh3-3,4-salpyr)](ClO4)2 (), and [N,N'-bis{5-[(triphenyl phosphonium chloride)-methyl]salicylidine}-2,3-diaminopyridine]Ni(ii) [Ni(5-CH2PPh3-2,3-salpyr)](ClO4)2 () have been isolated and characterized by elemental analysis, FT-IR, (1)H NMR, (13)C NMR, (31)P NMR, and UV-vis spectroscopy. The morphology and size of the nano complexes were determined using FE-SEM and TEM. In vitro DNA binding studies were investigated by UV-vis absorption spectroscopy, viscosity measurements, CD spectroscopy, cyclic voltammetry, emission spectra and gel electrophoresis, which suggest that the metal complexes act as efficient DNA binders. The absorption spectroscopy of the compounds with DNA reveals that the DNA binding affinity (Kb) has this order: > > > > > Ligand. The metal complexes show DNA binding stronger than the ligand, which is expected due to the nature of the metal. The nano complexes display DNA binding stronger than the other complexes which is related to the effect of size on binding affinity and the Ni(ii) complexes reveal DNA binding stronger than the corresponding Zn(ii) analogues, which is expected due to their z* effect and geometry. The prominent double strand DNA cleavage abilities of compound are observed in the absence of H2O2 with efficiencies of more than 50% even at 70 μM complex concentration. Surprisingly, Zn(ii) complexes (compounds & ) exhibit a higher cytotoxicity (IC50: 7.3 & 10.9 μM at 24 h; IC50: 4.6 & 8.7 μM at 48 h) against human hepatoma (HepG2) and HeLa cell lines than the Ni(ii) complexes (compounds , & ) and 5-fluorouracil as control in spite of their inability to cleave DNA. Finally, DNA binding interactions were performed by docking studies. Density functional theory (DFT) studies were performed using the GAUSSIAN 03 program. The DFT method with B3LYP functional, LANL2DZ basis set for metal centers and 6-311g* for other atoms was used. The synthesized compounds and DNA were simulated by molecular docking to explore more details of the ligands conformation and their orientations in the active site of the receptor." @default.
• W2296740576 created "2016-06-24" @default.
• W2296740576 creator A5008100330 @default.
• W2296740576 creator A5008766714 @default.
• W2296740576 creator A5017502540 @default.
• W2296740576 creator A5044286688 @default.
• W2296740576 creator A5057987969 @default.
• W2296740576 date "2016-01-01" @default.
• W2296740576 modified "2023-10-16" @default.
• W2296740576 title "Synthesis, characterization, DNA binding, cleavage activity, cytotoxicity and molecular docking of new nano water-soluble [M(5-CH₂PPh₃-3,4-salpyr)](ClO₄)₂(M = Ni, Zn) complexes" @default.
• W2296740576 cites W1523096735 @default.
• W2296740576 cites W1552266425 @default.
• W2296740576 cites W1599247225 @default.
• W2296740576 cites W1946400515 @default.
• W2296740576 cites W1963605029 @default.
• W2296740576 cites W1964081428 @default.
• W2296740576 cites W1965272410 @default.
• W2296740576 cites W1966414423 @default.
• W2296740576 cites W1969406326 @default.
• W2296740576 cites W1970393749 @default.
• W2296740576 cites W1970663919 @default.
• W2296740576 cites W1973406511 @default.
• W2296740576 cites W1974427934 @default.
• W2296740576 cites W1975402304 @default.
• W2296740576 cites W1978398904 @default.
• W2296740576 cites W1979135981 @default.
• W2296740576 cites W1980495221 @default.
• W2296740576 cites W1981172977 @default.
• W2296740576 cites W1983743657 @default.
• W2296740576 cites W1985789689 @default.
• W2296740576 cites W1987064540 @default.
• W2296740576 cites W1987268451 @default.
• W2296740576 cites W1988162290 @default.
• W2296740576 cites W1993826580 @default.
• W2296740576 cites W1995723298 @default.
• W2296740576 cites W1996163758 @default.
• W2296740576 cites W1997116722 @default.
• W2296740576 cites W1999547800 @default.
• W2296740576 cites W2000866464 @default.
• W2296740576 cites W2000922372 @default.
• W2296740576 cites W2007320138 @default.
• W2296740576 cites W2007579635 @default.
• W2296740576 cites W2010778735 @default.
• W2296740576 cites W2012108057 @default.
• W2296740576 cites W2013807825 @default.
• W2296740576 cites W2014046585 @default.
• W2296740576 cites W2014809337 @default.
• W2296740576 cites W2015665808 @default.
• W2296740576 cites W2016199163 @default.
• W2296740576 cites W2019696470 @default.
• W2296740576 cites W2019725236 @default.
• W2296740576 cites W2019828928 @default.
• W2296740576 cites W2023136182 @default.
• W2296740576 cites W2023689627 @default.
• W2296740576 cites W2024984449 @default.
• W2296740576 cites W2025846600 @default.
• W2296740576 cites W2027331102 @default.
• W2296740576 cites W2028714831 @default.
• W2296740576 cites W2029622237 @default.
• W2296740576 cites W2031215373 @default.
• W2296740576 cites W2031718525 @default.
• W2296740576 cites W2032444564 @default.
• W2296740576 cites W2034051571 @default.
• W2296740576 cites W2036622542 @default.
• W2296740576 cites W2036689892 @default.
• W2296740576 cites W2038822441 @default.
• W2296740576 cites W2042062103 @default.
• W2296740576 cites W2042268712 @default.
• W2296740576 cites W2043610941 @default.
• W2296740576 cites W2043855224 @default.
• W2296740576 cites W2044545507 @default.
• W2296740576 cites W2044890814 @default.
• W2296740576 cites W2049619686 @default.
• W2296740576 cites W2052048265 @default.
• W2296740576 cites W2053535968 @default.
• W2296740576 cites W2054524897 @default.
• W2296740576 cites W2057954591 @default.
• W2296740576 cites W2059179362 @default.
• W2296740576 cites W2062006936 @default.
• W2296740576 cites W2062066648 @default.
• W2296740576 cites W2064885067 @default.
• W2296740576 cites W2068989603 @default.
• W2296740576 cites W2070626372 @default.
• W2296740576 cites W2070716550 @default.
• W2296740576 cites W2070968982 @default.
• W2296740576 cites W2071420791 @default.
• W2296740576 cites W2073931531 @default.
• W2296740576 cites W2074210941 @default.
• W2296740576 cites W2074257185 @default.
• W2296740576 cites W2075331880 @default.
• W2296740576 cites W2075956831 @default.
• W2296740576 cites W2077709796 @default.
• W2296740576 cites W2080343419 @default.
• W2296740576 cites W2083355060 @default.
• W2296740576 cites W2085498498 @default.
• W2296740576 cites W2086924996 @default.
• W2296740576 cites W2089054022 @default.
• W2296740576 cites W2089523849 @default.

• next