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• W2296749708 abstract "Abstract Anti‐infectives used to treat chronic exuding wounds are diluted by wound exudates, absorbed into dressings, metabolised by proteases and destroyed by pH . In order to mimic such effects of exudates, the efficacy of six topical wound agents was assessed undiluted and at 10% concentrations, including povidone‐iodine ointment and a silver‐impregnated wound dressing, to remove biofilms of Pseudomonas aeruginosa , multi‐species biofilms of Candida albicans and methicillin‐resistant Staphylococcus aureus ( MRSA ) in vitro in a Centers for Disease Control and Prevention ( CDC ) reactor. Povidone‐iodine was also diluted to 3·3% and 33·3% of the commercial concentrations. Viable microorganisms in each preparation were quantified by colony count. No viable P. aeruginosa biofilm material was recovered after 4 and 24 hours of treatment with povidone‐iodine ointment at the 100% and 10% concentrations. No C. albicans / MRSA biofilm material was recovered after 4 and 24 hours of treatment with povidone‐iodine ointment at the 100% concentration. In general, following dilution, povidone‐iodine ointment appeared to exhibit greater biofilm removal than the other agents tested. Further research involving different microorganisms in vitro and in vivo over a longer period of time will help elucidate the full potential of povidone‐iodine ointment and liposomal hydrogel." @default.
• W2296749708 created "2016-06-24" @default.
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• W2296749708 date "2016-03-10" @default.
• W2296749708 modified "2023-10-12" @default.
• W2296749708 title "Povidone-iodine ointment demonstrates in vitro efficacy against biofilm formation" @default.
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• W2296749708 doi "https://doi.org/10.1111/iwj.12578" @default.
• W2296749708 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7949843" @default.
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