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• W2296776730 abstract "The lateral posterior and posterior thalamic nuclei have been implicated in aspects of visually guided behaviour and reflex responses to light, including those dependent on melanopsin photoreception. Here we investigated the extent and basic properties of visually evoked activity across the mouse lateral posterior and posterior thalamus. We show that a subset of retinal projections to these regions derive from melanopsin-expressing retinal ganglion cells and find many cells that exhibit melanopsin-dependent changes in firing. We also show that subsets of cells across these regions integrate signals from both eyes in various ways and that, within the lateral posterior thalamus, visual responses are retinotopically ordered.In addition to the primary thalamocortical visual relay in the lateral geniculate nuclei, a number of other thalamic regions contribute to aspects of visual processing. Thus, the lateral posterior thalamic nuclei (LP/pulvinar) appear important for various functions including determining visual saliency, visually guided behaviours and, alongside dorsal portions of the posterior thalamic nuclei (Po), multisensory processing of information related to aversive stimuli. However, despite the growing importance of mice as a model for understanding visual system organisation, at present we know very little about the basic visual response properties of cells in the mouse LP or Po. Prompted by earlier suggestions that melanopsin photoreception might be important for certain functions of these nuclei, we first employ specific viral tracing to show that a subset of retinal projections to the LP derive from melanopsin-expressing retinal ganglion cells. We next use multielectrode electrophysiology to demonstrate that LP and dorsal Po cells exhibit a variety of responses to simple visual stimuli including two distinct classes that express melanopsin-dependent changes in firing (together comprising ∼25% of neurons we recorded). We also show that subgroups of LP/Po cells integrate signals from both eyes in various ways and that, within the LP, visual responses are retinotopically ordered. Together our data reveal a diverse population of visually responsive neurons across the LP and dorsal Po whose properties align with some of the established functions of these nuclei and suggest new possible routes through which melanopsin photoreception could contribute to reflex light responses and/or higher order visual processing." @default.
• W2296776730 created "2016-06-24" @default.
• W2296776730 creator A5004568842 @default.
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• W2296776730 date "2016-03-31" @default.
• W2296776730 modified "2023-10-03" @default.
• W2296776730 title "Visual input to the mouse lateral posterior and posterior thalamic nuclei: photoreceptive origins and retinotopic order" @default.
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• W2296776730 cites W1591959848 @default.
• W2296776730 cites W1605438278 @default.
• W2296776730 cites W1622969568 @default.
• W2296776730 cites W1763543692 @default.
• W2296776730 cites W1909469768 @default.
• W2296776730 cites W1964180894 @default.
• W2296776730 cites W1964738011 @default.
• W2296776730 cites W1967071229 @default.
• W2296776730 cites W1968042048 @default.
• W2296776730 cites W1971254250 @default.
• W2296776730 cites W1972880784 @default.
• W2296776730 cites W1976833473 @default.
• W2296776730 cites W1983179302 @default.
• W2296776730 cites W1986300879 @default.
• W2296776730 cites W1986596083 @default.
• W2296776730 cites W1988048007 @default.
• W2296776730 cites W1992269759 @default.
• W2296776730 cites W1992967100 @default.
• W2296776730 cites W2004154740 @default.
• W2296776730 cites W2009077913 @default.
• W2296776730 cites W2011253476 @default.
• W2296776730 cites W2011825765 @default.
• W2296776730 cites W2013478809 @default.
• W2296776730 cites W2017108196 @default.
• W2296776730 cites W2023531960 @default.
• W2296776730 cites W2024966107 @default.
• W2296776730 cites W2032538800 @default.
• W2296776730 cites W2036239753 @default.
• W2296776730 cites W2037908367 @default.
• W2296776730 cites W2039726862 @default.
• W2296776730 cites W2043539548 @default.
• W2296776730 cites W2043864930 @default.
• W2296776730 cites W2043956980 @default.
• W2296776730 cites W2050912412 @default.
• W2296776730 cites W2052034821 @default.
• W2296776730 cites W2054335885 @default.
• W2296776730 cites W2056792189 @default.
• W2296776730 cites W2063309079 @default.
• W2296776730 cites W2067119585 @default.
• W2296776730 cites W2069398042 @default.
• W2296776730 cites W2073131876 @default.
• W2296776730 cites W2078340953 @default.
• W2296776730 cites W2081957674 @default.
• W2296776730 cites W2087328220 @default.
• W2296776730 cites W2088214898 @default.
• W2296776730 cites W2091697878 @default.
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• W2296776730 cites W2093879971 @default.
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• W2296776730 cites W2116056863 @default.
• W2296776730 cites W2116366629 @default.
• W2296776730 cites W2121735828 @default.
• W2296776730 cites W2139979304 @default.
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• W2296776730 cites W2146770948 @default.
• W2296776730 cites W2147949992 @default.
• W2296776730 cites W2149852316 @default.
• W2296776730 cites W2152412393 @default.
• W2296776730 cites W2157308120 @default.
• W2296776730 cites W2159777315 @default.
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• W2296776730 cites W2164172218 @default.
• W2296776730 cites W2167979998 @default.
• W2296776730 cites W2171448629 @default.
• W2296776730 cites W2287431041 @default.
• W2296776730 cites W2311917994 @default.
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• W2296776730 doi "https://doi.org/10.1113/jp271707" @default.
• W2296776730 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4818601" @default.
• W2296776730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26842995" @default.
• W2296776730 hasPublicationYear "2016" @default.
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