FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2296780006> ?p ?o ?g. }

• W2296780006 endingPage "34" @default.
• W2296780006 startingPage "223" @default.
• W2296780006 abstract "The purpose of this study was to assay for the presence of collagen synthesis stimulatory activity in the kidney during immune-induced renal injury that results in severe fibrosis in both glomerular and interstitial compartments. A model of antiglomerular basement (anti-GBM) disease in the rabbit was induced on day 0 by the injection of anti-GBM antibody and renal cortex tissues were then sampled at various time points. Only conditioned media prepared from diseased renal cortical samples showed collagen synthesis stimulatory activity when tested on rabbit mesangial cells. The activity had an estimated molecular weight range of 16 to 25 kd and was neutralized by antibody to transforming growth factor-beta (TGF-beta). A standard assay for TGF-beta using a mink lung epithelial cell line confirmed the increase in TGF-beta activity in conditioned media of diseased cortex from day 7 and day 14 animals, which was not significantly activated by previous acidification. This suggests that most of the TGF-beta present in renal conditioned media was in the active form. The increase in renal cortical secretion of active TGF-beta was accompanied by increases in renal cortical TGF-beta mRNA content on days 4 and 7 after induction, with subsequent return to control levels. A similar increase in TGF-beta activity was present in nonacidified conditioned media of purified glomeruli from diseased days 7 and 14 animals, which was also accompanied by significant increases in TGF-beta mRNA. However with acidification no significant differences were noted between control and diseased samples, suggesting the presence of substantial latent TGF-beta activity in control glomerular conditioned media. These same control-conditioned media contained inhibitor activity for added exogenous TGF-beta. These results support the conclusion that the association between increased TGF-beta secretion and increased renal cortical collagen synthesis in this model is consistent with a role for this cytokine in directing fibrogenesis in the kidney." @default.
• W2296780006 created "2016-06-24" @default.
• W2296780006 creator A5013157599 @default.
• W2296780006 creator A5031139887 @default.
• W2296780006 creator A5033054221 @default.
• W2296780006 creator A5077346838 @default.
• W2296780006 creator A5091628952 @default.
• W2296780006 date "1991-01-01" @default.
• W2296780006 modified "2023-09-23" @default.
• W2296780006 title "Transforming growth factor-beta production in anti-glomerular basement membrane disease in the rabbit." @default.
• W2296780006 cites W1481992428 @default.
• W2296780006 cites W1497695953 @default.
• W2296780006 cites W1505978562 @default.
• W2296780006 cites W1510586846 @default.
• W2296780006 cites W1513452394 @default.
• W2296780006 cites W1528585209 @default.
• W2296780006 cites W1560768456 @default.
• W2296780006 cites W1654490530 @default.
• W2296780006 cites W1971878230 @default.
• W2296780006 cites W1975482451 @default.
• W2296780006 cites W1978659501 @default.
• W2296780006 cites W1979877257 @default.
• W2296780006 cites W1993402154 @default.
• W2296780006 cites W1993851092 @default.
• W2296780006 cites W1997419670 @default.
• W2296780006 cites W2002491528 @default.
• W2296780006 cites W2007534712 @default.
• W2296780006 cites W2007768242 @default.
• W2296780006 cites W2010710364 @default.
• W2296780006 cites W2014669590 @default.
• W2296780006 cites W2029007336 @default.
• W2296780006 cites W2041149723 @default.
• W2296780006 cites W2060333964 @default.
• W2296780006 cites W2062199188 @default.
• W2296780006 cites W2062510144 @default.
• W2296780006 cites W2064566876 @default.
• W2296780006 cites W2066670280 @default.
• W2296780006 cites W2069515234 @default.
• W2296780006 cites W2072558376 @default.
• W2296780006 cites W2091614482 @default.
• W2296780006 cites W2108104357 @default.
• W2296780006 cites W2129965949 @default.
• W2296780006 cites W2146559746 @default.
• W2296780006 cites W2153549628 @default.
• W2296780006 cites W2155383324 @default.
• W2296780006 cites W2161454032 @default.
• W2296780006 cites W2164094961 @default.
• W2296780006 cites W2168476587 @default.
• W2296780006 cites W2215746169 @default.
• W2296780006 cites W225146660 @default.
• W2296780006 cites W2414627296 @default.
• W2296780006 cites W2414793515 @default.
• W2296780006 cites W2417146444 @default.
• W2296780006 cites W2418991305 @default.
• W2296780006 cites W2468764334 @default.
• W2296780006 cites W2576734941 @default.
• W2296780006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1886059" @default.
• W2296780006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1987768" @default.
• W2296780006 hasPublicationYear "1991" @default.
• W2296780006 type Work @default.
• W2296780006 sameAs 2296780006 @default.
• W2296780006 citedByCount "42" @default.
• W2296780006 countsByYear W22967800062017 @default.
• W2296780006 crossrefType "journal-article" @default.
• W2296780006 hasAuthorship W2296780006A5013157599 @default.
• W2296780006 hasAuthorship W2296780006A5031139887 @default.
• W2296780006 hasAuthorship W2296780006A5033054221 @default.
• W2296780006 hasAuthorship W2296780006A5077346838 @default.
• W2296780006 hasAuthorship W2296780006A5091628952 @default.
• W2296780006 hasConcept C118131993 @default.
• W2296780006 hasConcept C126322002 @default.
• W2296780006 hasConcept C134018914 @default.
• W2296780006 hasConcept C159654299 @default.
• W2296780006 hasConcept C169760540 @default.
• W2296780006 hasConcept C185592680 @default.
• W2296780006 hasConcept C199360897 @default.
• W2296780006 hasConcept C203014093 @default.
• W2296780006 hasConcept C2776174256 @default.
• W2296780006 hasConcept C2776193487 @default.
• W2296780006 hasConcept C2777348757 @default.
• W2296780006 hasConcept C2778229498 @default.
• W2296780006 hasConcept C2778577996 @default.
• W2296780006 hasConcept C2780091579 @default.
• W2296780006 hasConcept C41008148 @default.
• W2296780006 hasConcept C49039625 @default.
• W2296780006 hasConcept C71924100 @default.
• W2296780006 hasConcept C86803240 @default.
• W2296780006 hasConcept C95444343 @default.
• W2296780006 hasConceptScore W2296780006C118131993 @default.
• W2296780006 hasConceptScore W2296780006C126322002 @default.
• W2296780006 hasConceptScore W2296780006C134018914 @default.
• W2296780006 hasConceptScore W2296780006C159654299 @default.
• W2296780006 hasConceptScore W2296780006C169760540 @default.
• W2296780006 hasConceptScore W2296780006C185592680 @default.
• W2296780006 hasConceptScore W2296780006C199360897 @default.
• W2296780006 hasConceptScore W2296780006C203014093 @default.
• W2296780006 hasConceptScore W2296780006C2776174256 @default.
• W2296780006 hasConceptScore W2296780006C2776193487 @default.

• next