FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2296842014> ?p ?o ?g. }

• W2296842014 endingPage "47" @default.
• W2296842014 startingPage "41" @default.
• W2296842014 abstract "Introduction: Essential Thrombocythemia (ET) is a clonal myeloproliferative disease presenting predominantly with thrombocytosis. One of its rare complications is leukemic transformation (LT). Once leukemic transformation occurs, prognosis is dismal. We aim to determine the disease profile of LT in our ET patients and evaluate if chemotherapy can alter prognosis. Methods: Clinical data of all patients diagnosed and treated with ET from 1999 to 2008 in the Department of Hematology, Singapore General Hospital, were captured in the Myeloproliferative Disease(MPD) Registry. ET patients with LT were selected. Patient characteristics, disease profile, including ET treatment, duration from ET diagnosis to LT, prior myelofibrosis (MF) history, type of chemotherapy, response and eventual survival were recorded. Results: Two hundred and thirty ET patients were diagnosed and treated from 1999 to 2008. Six patients had LT (2.6%). All were Chinese. Four were females. Age range was 47–70 years (mean 61.2 years). Transformation to acute myeloid leukemia (AML) was seen in 5 patients, after a latency period of 3–28 years. Acute biphenotypic leukemia was diagnosed in 1 patient 4 years after ET diagnosis. All patients had received hydroxyurea. There was no prior evolution to MF. Complex cytogenetics were seen in all cases. Three patients treated conservatively died within 1 month. The other 3 patients did not go into durable complete remission despite chemotherapy and succumbed within 9 months. Conclusions: Leukemic transformation in ET, though rare, is associated with grave prognosis. Outcome with chemotherapy is dismal. More studies are needed to evaluate if alternative treatment can improve survival." @default.
• W2296842014 created "2016-06-24" @default.
• W2296842014 creator A5069975862 @default.
• W2296842014 date "2011-03-01" @default.
• W2296842014 modified "2023-09-24" @default.
• W2296842014 title "Should Chemotherapy Be Administered for Essential Thrombocythemia (ET) Patients with Leukemic Transformation?" @default.
• W2296842014 cites W1571376117 @default.
• W2296842014 cites W1887989049 @default.
• W2296842014 cites W1975825540 @default.
• W2296842014 cites W1980050196 @default.
• W2296842014 cites W1990444790 @default.
• W2296842014 cites W1993214853 @default.
• W2296842014 cites W1998721150 @default.
• W2296842014 cites W2010957760 @default.
• W2296842014 cites W2024550450 @default.
• W2296842014 cites W2028835250 @default.
• W2296842014 cites W2030391513 @default.
• W2296842014 cites W2033303986 @default.
• W2296842014 cites W2053584669 @default.
• W2296842014 cites W2060108619 @default.
• W2296842014 cites W2067806450 @default.
• W2296842014 cites W2069651950 @default.
• W2296842014 cites W2076231724 @default.
• W2296842014 cites W2082997796 @default.
• W2296842014 cites W2087623186 @default.
• W2296842014 cites W2087946529 @default.
• W2296842014 cites W2093216476 @default.
• W2296842014 cites W2112316414 @default.
• W2296842014 cites W2160228508 @default.
• W2296842014 cites W2167851932 @default.
• W2296842014 cites W2318933236 @default.
• W2296842014 cites W2320032845 @default.
• W2296842014 cites W46453237 @default.
• W2296842014 doi "https://doi.org/10.1177/201010581102000107" @default.
• W2296842014 hasPublicationYear "2011" @default.
• W2296842014 type Work @default.
• W2296842014 sameAs 2296842014 @default.
• W2296842014 citedByCount "0" @default.
• W2296842014 crossrefType "journal-article" @default.
• W2296842014 hasAuthorship W2296842014A5069975862 @default.
• W2296842014 hasBestOaLocation W22968420141 @default.
• W2296842014 hasConcept C126322002 @default.
• W2296842014 hasConcept C141071460 @default.
• W2296842014 hasConcept C194409129 @default.
• W2296842014 hasConcept C2776694085 @default.
• W2296842014 hasConcept C2778461978 @default.
• W2296842014 hasConcept C2778729363 @default.
• W2296842014 hasConcept C2778837598 @default.
• W2296842014 hasConcept C2779134260 @default.
• W2296842014 hasConcept C2779316324 @default.
• W2296842014 hasConcept C2779788118 @default.
• W2296842014 hasConcept C2780007613 @default.
• W2296842014 hasConcept C2780076729 @default.
• W2296842014 hasConcept C2781057849 @default.
• W2296842014 hasConcept C71924100 @default.
• W2296842014 hasConcept C89560881 @default.
• W2296842014 hasConceptScore W2296842014C126322002 @default.
• W2296842014 hasConceptScore W2296842014C141071460 @default.
• W2296842014 hasConceptScore W2296842014C194409129 @default.
• W2296842014 hasConceptScore W2296842014C2776694085 @default.
• W2296842014 hasConceptScore W2296842014C2778461978 @default.
• W2296842014 hasConceptScore W2296842014C2778729363 @default.
• W2296842014 hasConceptScore W2296842014C2778837598 @default.
• W2296842014 hasConceptScore W2296842014C2779134260 @default.
• W2296842014 hasConceptScore W2296842014C2779316324 @default.
• W2296842014 hasConceptScore W2296842014C2779788118 @default.
• W2296842014 hasConceptScore W2296842014C2780007613 @default.
• W2296842014 hasConceptScore W2296842014C2780076729 @default.
• W2296842014 hasConceptScore W2296842014C2781057849 @default.
• W2296842014 hasConceptScore W2296842014C71924100 @default.
• W2296842014 hasConceptScore W2296842014C89560881 @default.
• W2296842014 hasIssue "1" @default.
• W2296842014 hasLocation W22968420141 @default.
• W2296842014 hasOpenAccess W2296842014 @default.
• W2296842014 hasPrimaryLocation W22968420141 @default.
• W2296842014 hasRelatedWork W1969315976 @default.
• W2296842014 hasRelatedWork W1984010596 @default.
• W2296842014 hasRelatedWork W1990387953 @default.
• W2296842014 hasRelatedWork W1990520184 @default.
• W2296842014 hasRelatedWork W2032878929 @default.
• W2296842014 hasRelatedWork W2082997796 @default.
• W2296842014 hasRelatedWork W2168062293 @default.
• W2296842014 hasRelatedWork W2296842014 @default.
• W2296842014 hasRelatedWork W2339786185 @default.
• W2296842014 hasRelatedWork W2396063618 @default.
• W2296842014 hasVolume "20" @default.
• W2296842014 isParatext "false" @default.
• W2296842014 isRetracted "false" @default.
• W2296842014 magId "2296842014" @default.
• W2296842014 workType "article" @default.