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- W2296905641 abstract "In budding yeast, targeting of active genes to the nuclear pore complex (NPC) and interchromosomal clustering is mediated by transcription factor (TF) binding sites in the gene promoters. For example, the binding sites for the TFs Put3, Ste12, and Gcn4 are necessary and sufficient to promote positioning at the nuclear periphery and interchromosomal clustering. However, in all three cases, gene positioning and interchromosomal clustering are regulated. Under uninducing conditions, local recruitment of the Rpd3(L) histone deacetylase by transcriptional repressors blocks Put3 DNA binding. This is a general function of yeast repressors: 16 of 21 repressors blocked Put3-mediated subnuclear positioning; 11 of these required Rpd3. In contrast, Ste12-mediated gene positioning is regulated independently of DNA binding by mitogen-activated protein kinase phosphorylation of the Dig2 inhibitor, and Gcn4-dependent targeting is up-regulated by increasing Gcn4 protein levels. These different regulatory strategies provide either qualitative switch-like control or quantitative control of gene positioning over different time scales." @default.
- W2296905641 created "2016-06-24" @default.
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- W2296905641 date "2016-03-07" @default.
- W2296905641 modified "2023-10-13" @default.
- W2296905641 title "Strategies to regulate transcription factor–mediated gene positioning and interchromosomal clustering at the nuclear periphery" @default.
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- W2296905641 doi "https://doi.org/10.1083/jcb.201508068" @default.
- W2296905641 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4792077" @default.
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- W2296905641 hasPublicationYear "2016" @default.
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