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- W2296908257 abstract "A higher risk of breast cancer has been recorded in current or recent users of Depo-Provera and oral contraceptives (OCs) than women who have not taken steroid hormones for 5 or more years. Given the observation that OCs protect users from both fibroadenoma and fibrocystic disease it is hypothesized that the higher risk of breast cancer among current or recent steroid hormone acceptors may reflect an unmasking effect due to the suppression of benign breast disease by these drugs. A malignant lump would be more easily detected in a steroid contraceptive user with suppressed benign breast disease than in a nonuser with active benign breast disease; in the latter case radiographically dense breast can mask early malignant tumors. Support for this theory is provided by the greater incidence of benign breast disease in women under 45 years of age and the increased risk of OC-associated breast cancer only in women in this age group. To eliminate possible early detection bias in studies of breast cancer and hormonal contraceptive use it is recommended that data on the presence and extent of benign breast disease at the time of breast cancer diagnosis be collected." @default.
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- W2296908257 title "Depot medroxyprogesterone and risk of breast cancer [letter]" @default.
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