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- W2296912137 abstract "11 women taking Ovosiston/0.08 mg mestranol and 2.0 mg chlormadinoacetate/12 taking Gravistat or Non-Ovlon/0.05 mg ethinylestradiol and 0.125 mg levonorgestrel 0.05 mg ethinylestradiol and 1.0 mg norethisteranoacetate/ and 8 taking Minisiston or Trisiston/0.03 mg ethinylestradiol and 0.125 mg levonorgestrel as well as a triphasic levonorgestrel and ethinylestradiol combination/for 1-3 years with an average age of 27.4 years had their basal serum prolactin level determined on the 19th-21st day of use and additionally the 30- and 60-minute values were obtained after iv injection of Cerucal/metoclopramidehydrochloride/. A control group of 6 women with regular biphasic cycle and average age of 24.3 years were compared to this group of 31 subjects. In addition 5 more women taking oral contraceptives were given a double dose of 200 mcg thyrone-releasing hormone/TRH/ and compared to 2 controls. 7 women had prolactin values over 1000 mU/1/ the normal upper limit was 700 mU/1/. The difference was statistically significant between the Ovosiston and Gravistat/Non-Ovlon groups and the controls. Although double stimulation with 200 mcg TRH was less effective in triggering prolactin release women taking oral contraceptives also showed increased levels compared to controls. The metoclopramide-induced values were not different in the 4 groups of subjects. In view of hitherto negative epidemiological findings and the antagonistic effect of gestagen on the estrogen contained in pills the promotion of prolactinoma by oral contraceptives is very unlikely." @default.
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- W2296912137 date "1988-01-01" @default.
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- W2296912137 title "Studies on prolactin stimulation with metoclopramide in women on oral contraceptives" @default.
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