FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2296916815> ?p ?o ?g. }

• W2296916815 endingPage "2182" @default.
• W2296916815 startingPage "2168" @default.
• W2296916815 abstract "Recently, we have shown that (S)-N'-Nitrosonornicotine [(S)-NNN], the major form of NNN in tobacco products, is a potent oral cavity and esophageal carcinogen in rats. To determine the early molecular alterations induced by (S)-NNN in the oral and esophageal mucosa, we administered the carcinogen to rats in the drinking water for 10 wk and global gene expression alterations were analyzed by RNA sequencing. At a false discovery rate P-value < 0.05 and fold-change ≥2, we found alterations in the level of 39 genes in the oral cavity and 69 genes in the esophagus. Validation of RNA sequencing results by qRT-PCR assays revealed a high cross-platform concordance. The most significant impact of exposure to (S)-NNN was alteration of genes involved in immune regulation (Aire, Ctla4, and CD80), inflammation (Ephx2 and Inpp5d) and cancer (Cdkn2a, Dhh, Fetub B, Inpp5d, Ly6E, Nr1d1, and Wnt6). Consistent with the findings in rat tissues, most of the genes were deregulated, albeit to different degrees, in immortalized oral keratinocytes treated with (S)-NNN and in non-treated premalignant oral cells and malignant oral and head and neck squamous cells. Furthermore, interrogation of TCGA data sets showed that genes deregulated by (S)-NNN in rat tissues (Fetub, Ly6e, Nr1d1, Cacna1c, Cd80, and Dgkg) are also altered in esophageal and head and neck tumors. Overall, our findings provide novel insights into early molecular changes induced by (S)-NNN and, therefore, could contribute to the development of biomarkers for the early detection and prevention of (S)-NNN-associated oral and esophageal cancers. © 2016 Wiley Periodicals, Inc." @default.
• W2296916815 created "2016-06-24" @default.
• W2296916815 creator A5001476935 @default.
• W2296916815 creator A5033402104 @default.
• W2296916815 creator A5036639936 @default.
• W2296916815 creator A5037811012 @default.
• W2296916815 creator A5040985457 @default.
• W2296916815 creator A5047824419 @default.
• W2296916815 creator A5049136467 @default.
• W2296916815 creator A5053303854 @default.
• W2296916815 creator A5062371918 @default.
• W2296916815 creator A5072241229 @default.
• W2296916815 date "2016-01-19" @default.
• W2296916815 modified "2023-09-26" @default.
• W2296916815 title "Transcriptome profiling in oral cavity and esophagus tissues from (<i>S</i>)-N′-nitrosonornicotine-treated rats reveals candidate genes involved in human oral cavity and esophageal carcinogenesis" @default.
• W2296916815 cites W1526215225 @default.
• W2296916815 cites W1530850449 @default.
• W2296916815 cites W1569227242 @default.
• W2296916815 cites W1620536498 @default.
• W2296916815 cites W1887882764 @default.
• W2296916815 cites W1975219953 @default.
• W2296916815 cites W1982415055 @default.
• W2296916815 cites W1986241711 @default.
• W2296916815 cites W1999453109 @default.
• W2296916815 cites W1999574084 @default.
• W2296916815 cites W2003098351 @default.
• W2296916815 cites W2008254158 @default.
• W2296916815 cites W2011387381 @default.
• W2296916815 cites W2015676500 @default.
• W2296916815 cites W2017065573 @default.
• W2296916815 cites W2025246823 @default.
• W2296916815 cites W2030646647 @default.
• W2296916815 cites W2033305155 @default.
• W2296916815 cites W2048217782 @default.
• W2296916815 cites W2049647656 @default.
• W2296916815 cites W2051087584 @default.
• W2296916815 cites W2055018340 @default.
• W2296916815 cites W2065123319 @default.
• W2296916815 cites W2066503677 @default.
• W2296916815 cites W2066632633 @default.
• W2296916815 cites W2070611230 @default.
• W2296916815 cites W2077680842 @default.
• W2296916815 cites W2090001690 @default.
• W2296916815 cites W2091067872 @default.
• W2296916815 cites W2092656025 @default.
• W2296916815 cites W2093335403 @default.
• W2296916815 cites W2094834099 @default.
• W2296916815 cites W2098749503 @default.
• W2296916815 cites W2104231624 @default.
• W2296916815 cites W2104518333 @default.
• W2296916815 cites W2106552859 @default.
• W2296916815 cites W2107006646 @default.
• W2296916815 cites W2114104545 @default.
• W2296916815 cites W2114843025 @default.
• W2296916815 cites W2119923823 @default.
• W2296916815 cites W2122769974 @default.
• W2296916815 cites W2125169413 @default.
• W2296916815 cites W2127996482 @default.
• W2296916815 cites W2145105613 @default.
• W2296916815 cites W2145350167 @default.
• W2296916815 cites W2145630011 @default.
• W2296916815 cites W2149802583 @default.
• W2296916815 cites W2152239989 @default.
• W2296916815 cites W2155144538 @default.
• W2296916815 cites W2159665593 @default.
• W2296916815 cites W2262513754 @default.
• W2296916815 doi "https://doi.org/10.1002/mc.22459" @default.
• W2296916815 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5142294" @default.
• W2296916815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26785143" @default.
• W2296916815 hasPublicationYear "2016" @default.
• W2296916815 type Work @default.
• W2296916815 sameAs 2296916815 @default.
• W2296916815 citedByCount "7" @default.
• W2296916815 countsByYear W22969168152016 @default.
• W2296916815 countsByYear W22969168152018 @default.
• W2296916815 countsByYear W22969168152019 @default.
• W2296916815 countsByYear W22969168152021 @default.
• W2296916815 countsByYear W22969168152022 @default.
• W2296916815 countsByYear W22969168152023 @default.
• W2296916815 crossrefType "journal-article" @default.
• W2296916815 hasAuthorship W2296916815A5001476935 @default.
• W2296916815 hasAuthorship W2296916815A5033402104 @default.
• W2296916815 hasAuthorship W2296916815A5036639936 @default.
• W2296916815 hasAuthorship W2296916815A5037811012 @default.
• W2296916815 hasAuthorship W2296916815A5040985457 @default.
• W2296916815 hasAuthorship W2296916815A5047824419 @default.
• W2296916815 hasAuthorship W2296916815A5049136467 @default.
• W2296916815 hasAuthorship W2296916815A5053303854 @default.
• W2296916815 hasAuthorship W2296916815A5062371918 @default.
• W2296916815 hasAuthorship W2296916815A5072241229 @default.
• W2296916815 hasBestOaLocation W22969168152 @default.
• W2296916815 hasConcept C104317684 @default.
• W2296916815 hasConcept C105702510 @default.
• W2296916815 hasConcept C114246631 @default.
• W2296916815 hasConcept C142724271 @default.
• W2296916815 hasConcept C150194340 @default.
• W2296916815 hasConcept C153911025 @default.
• W2296916815 hasConcept C162317418 @default.

• next