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- W2296927341 abstract "Incorporation of new neurons enables plasticity and repair of circuits in the adult brain. Adult neurogenesis is a key feature of the mammalian olfactory system, with new olfactory sensory neurons (OSNs) wiring into highly organized olfactory bulb (OB) circuits throughout life. However, neither when new postnatally generated OSNs first form synapses nor whether OSNs retain the capacity for synaptogenesis once mature, is known. Therefore, how integration of adult-born OSNs may contribute to lifelong OB plasticity is unclear. Here, we use a combination of electron microscopy, optogenetic activation and in vivo time-lapse imaging to show that newly generated OSNs form highly dynamic synapses and are capable of eliciting robust stimulus-locked firing of neurons in the mouse OB. Furthermore, we demonstrate that mature OSN axons undergo continuous activity-dependent synaptic remodelling that persists into adulthood. OSN synaptogenesis, therefore, provides a sustained potential for OB plasticity and repair that is much faster than OSN replacement alone." @default.
- W2296927341 created "2016-06-24" @default.
- W2296927341 creator A5024284914 @default.
- W2296927341 creator A5034925988 @default.
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- W2296927341 date "2016-02-22" @default.
- W2296927341 modified "2023-10-11" @default.
- W2296927341 title "Rapid and continuous activity-dependent plasticity of olfactory sensory input" @default.
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- W2296927341 cites W1966155655 @default.
- W2296927341 cites W1974043427 @default.
- W2296927341 cites W1976485053 @default.
- W2296927341 cites W1977169670 @default.
- W2296927341 cites W1977576332 @default.
- W2296927341 cites W1979019425 @default.
- W2296927341 cites W1979646284 @default.
- W2296927341 cites W1980398120 @default.
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- W2296927341 doi "https://doi.org/10.1038/ncomms10729" @default.
- W2296927341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4764868" @default.
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