Matches in SemOpenAlex for { <https://semopenalex.org/work/W2296929994> ?p ?o ?g. }
- W2296929994 endingPage "1920" @default.
- W2296929994 startingPage "1910" @default.
- W2296929994 abstract "Toluene is an organic solvent that is used in various industrial applications. Despite its usefulness, toluene has toxic effects on the brain and is a substance that is commonly abused. Toluene causes behavioral and functional abnormalities such as decreased memory capacity, cognitive impairment, and depression-like symptoms. However, the target sites and toxic mechanisms of inhaled toluene in the brain are poorly understood. In this study, we subjected Sprague-Dawley (SD) rats to acute high-level toluene exposure (7000 ppm) to investigate its neuronal toxicity, and in particular, its effect on neurogenesis in the hippocampus. In order to assay the effects of inhaled toluene on hippocampal neurogenesis, we measured the levels of neurogenesis markers Ki-67 and doublecortin (DCX) in the hippocampus 1, 2, 5, and 8 days after cessation of toluene exposure. In addition to assaying clinical signs, body weight, and bronchoalveolar lavage fluid, the liver, lungs, and kidneys were subjected to histopathological examination to investigate the toxic effects of high-level toluene exposure. Although abnormal neurological signs were observed after toluene exposure, these disappeared within 24 h and no toluene-related toxicological effects were observed in the liver, lungs, or kidneys. The animals exposed to toluene showed significantly decreased hippocampal neurogenesis, which persisted until the 8th and final day of measurement. Thus, acute high-level toluene exposure inhibited hippocampal neurogenesis and produced transient abnormal neurological signs, but did not produce toxicity in the other organs studied." @default.
- W2296929994 created "2016-06-24" @default.
- W2296929994 creator A5009261338 @default.
- W2296929994 creator A5012029897 @default.
- W2296929994 creator A5039479216 @default.
- W2296929994 creator A5055974749 @default.
- W2296929994 creator A5082996802 @default.
- W2296929994 date "2016-07-09" @default.
- W2296929994 modified "2023-09-23" @default.
- W2296929994 title "Acute high-level toluene exposure decreases hippocampal neurogenesis in rats" @default.
- W2296929994 cites W1965587913 @default.
- W2296929994 cites W1967606302 @default.
- W2296929994 cites W1974208182 @default.
- W2296929994 cites W1976981256 @default.
- W2296929994 cites W1985626698 @default.
- W2296929994 cites W1988768611 @default.
- W2296929994 cites W1991357897 @default.
- W2296929994 cites W1994345197 @default.
- W2296929994 cites W2000766834 @default.
- W2296929994 cites W2005216394 @default.
- W2296929994 cites W2005920075 @default.
- W2296929994 cites W2011488751 @default.
- W2296929994 cites W2015476521 @default.
- W2296929994 cites W2026690061 @default.
- W2296929994 cites W2029154656 @default.
- W2296929994 cites W2034160931 @default.
- W2296929994 cites W2048471300 @default.
- W2296929994 cites W2049633540 @default.
- W2296929994 cites W2069368743 @default.
- W2296929994 cites W2079061876 @default.
- W2296929994 cites W2082982181 @default.
- W2296929994 cites W2093574347 @default.
- W2296929994 cites W2094996784 @default.
- W2296929994 cites W2101486622 @default.
- W2296929994 cites W2113243553 @default.
- W2296929994 cites W2141041835 @default.
- W2296929994 cites W2144161205 @default.
- W2296929994 cites W2144176385 @default.
- W2296929994 cites W2151672884 @default.
- W2296929994 cites W2167639057 @default.
- W2296929994 cites W4243703252 @default.
- W2296929994 cites W72712193 @default.
- W2296929994 doi "https://doi.org/10.1177/0748233715599087" @default.
- W2296929994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26475279" @default.
- W2296929994 hasPublicationYear "2016" @default.
- W2296929994 type Work @default.
- W2296929994 sameAs 2296929994 @default.
- W2296929994 citedByCount "12" @default.
- W2296929994 countsByYear W22969299942016 @default.
- W2296929994 countsByYear W22969299942017 @default.
- W2296929994 countsByYear W22969299942018 @default.
- W2296929994 countsByYear W22969299942019 @default.
- W2296929994 countsByYear W22969299942020 @default.
- W2296929994 countsByYear W22969299942021 @default.
- W2296929994 countsByYear W22969299942022 @default.
- W2296929994 crossrefType "journal-article" @default.
- W2296929994 hasAuthorship W2296929994A5009261338 @default.
- W2296929994 hasAuthorship W2296929994A5012029897 @default.
- W2296929994 hasAuthorship W2296929994A5039479216 @default.
- W2296929994 hasAuthorship W2296929994A5055974749 @default.
- W2296929994 hasAuthorship W2296929994A5082996802 @default.
- W2296929994 hasConcept C126322002 @default.
- W2296929994 hasConcept C134018914 @default.
- W2296929994 hasConcept C148762608 @default.
- W2296929994 hasConcept C15744967 @default.
- W2296929994 hasConcept C169760540 @default.
- W2296929994 hasConcept C178790620 @default.
- W2296929994 hasConcept C185592680 @default.
- W2296929994 hasConcept C2776464000 @default.
- W2296929994 hasConcept C2778142098 @default.
- W2296929994 hasConcept C2781161787 @default.
- W2296929994 hasConcept C2781461022 @default.
- W2296929994 hasConcept C29730261 @default.
- W2296929994 hasConcept C4746552 @default.
- W2296929994 hasConcept C71924100 @default.
- W2296929994 hasConceptScore W2296929994C126322002 @default.
- W2296929994 hasConceptScore W2296929994C134018914 @default.
- W2296929994 hasConceptScore W2296929994C148762608 @default.
- W2296929994 hasConceptScore W2296929994C15744967 @default.
- W2296929994 hasConceptScore W2296929994C169760540 @default.
- W2296929994 hasConceptScore W2296929994C178790620 @default.
- W2296929994 hasConceptScore W2296929994C185592680 @default.
- W2296929994 hasConceptScore W2296929994C2776464000 @default.
- W2296929994 hasConceptScore W2296929994C2778142098 @default.
- W2296929994 hasConceptScore W2296929994C2781161787 @default.
- W2296929994 hasConceptScore W2296929994C2781461022 @default.
- W2296929994 hasConceptScore W2296929994C29730261 @default.
- W2296929994 hasConceptScore W2296929994C4746552 @default.
- W2296929994 hasConceptScore W2296929994C71924100 @default.
- W2296929994 hasIssue "11" @default.
- W2296929994 hasLocation W22969299941 @default.
- W2296929994 hasLocation W22969299942 @default.
- W2296929994 hasOpenAccess W2296929994 @default.
- W2296929994 hasPrimaryLocation W22969299941 @default.
- W2296929994 hasRelatedWork W128272490 @default.
- W2296929994 hasRelatedWork W1805625510 @default.
- W2296929994 hasRelatedWork W1974742404 @default.
- W2296929994 hasRelatedWork W2033129426 @default.