Matches in SemOpenAlex for { <https://semopenalex.org/work/W2296943863> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2296943863 endingPage "21" @default.
- W2296943863 startingPage "3015" @default.
- W2296943863 abstract "To establish a new mouse model for wound healing studies on hemophilia A.Total 54 male mice with different genotypes including wild-type nude mice, heterozygous mice (FVIII-/-/Nu) and FVIII deficient mice (FVIII-/-) were generated and verified by PCR. Mice were subjected to wound healing research by making a 5 mm-thickness wound on mice skin and applying recombinant human epidermal growth factor (EGF, 10 μg/g) ointment, FVIII ointment (30 IU) or the ointment base to heal the wounds. Furthermore, keratinocytes were isolated from these newborn mice and subjected to migration assay by stimulation of EGF (ng/ml), insulin (10 μM) or vehicle.A new hemophilic mouse model (FVIII-/-/Nu) was constructed successfully after genotyping verified by PCR. Compared to FVIII-/- mice, FVIII-/-/Nu and Nu mice showed greater degree of wound contraction and loss of the crust. Topical treatment with EGF exhibited faster wound healing than FVIII and ointment base. Insulin treatment showed more increased migration distance than treated with EGF or vehicle. FVIII-/-/Nu mice showed greater migration than FVIII-/- and Nu mice.A new mouse model (FVIII-/-/Nu) for wound healing in hemophilia A was constructed, and topical treatment of insulin may be a better therapy than EGF for healing wounds in hemophilia A." @default.
- W2296943863 created "2016-06-24" @default.
- W2296943863 creator A5002207602 @default.
- W2296943863 creator A5002509297 @default.
- W2296943863 creator A5066059291 @default.
- W2296943863 creator A5083803125 @default.
- W2296943863 date "2015-01-01" @default.
- W2296943863 modified "2023-09-23" @default.
- W2296943863 title "A new mouse model for wound healing in hemophilia A." @default.
- W2296943863 cites W1568644509 @default.
- W2296943863 cites W164067101 @default.
- W2296943863 cites W1773954132 @default.
- W2296943863 cites W189464135 @default.
- W2296943863 cites W1927036797 @default.
- W2296943863 cites W1968660753 @default.
- W2296943863 cites W1972457736 @default.
- W2296943863 cites W1974243133 @default.
- W2296943863 cites W1983064526 @default.
- W2296943863 cites W1986308133 @default.
- W2296943863 cites W1989888025 @default.
- W2296943863 cites W1990060082 @default.
- W2296943863 cites W1998524291 @default.
- W2296943863 cites W2006951732 @default.
- W2296943863 cites W2022674745 @default.
- W2296943863 cites W2040409790 @default.
- W2296943863 cites W2057877210 @default.
- W2296943863 cites W2059848729 @default.
- W2296943863 cites W2060119002 @default.
- W2296943863 cites W2070995184 @default.
- W2296943863 cites W2073227556 @default.
- W2296943863 cites W2164199105 @default.
- W2296943863 cites W2386759215 @default.
- W2296943863 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4440121" @default.
- W2296943863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26045812" @default.
- W2296943863 hasPublicationYear "2015" @default.
- W2296943863 type Work @default.
- W2296943863 sameAs 2296943863 @default.
- W2296943863 citedByCount "2" @default.
- W2296943863 countsByYear W22969438632018 @default.
- W2296943863 countsByYear W22969438632019 @default.
- W2296943863 crossrefType "journal-article" @default.
- W2296943863 hasAuthorship W2296943863A5002207602 @default.
- W2296943863 hasAuthorship W2296943863A5002509297 @default.
- W2296943863 hasAuthorship W2296943863A5066059291 @default.
- W2296943863 hasAuthorship W2296943863A5083803125 @default.
- W2296943863 hasConcept C104317684 @default.
- W2296943863 hasConcept C185592680 @default.
- W2296943863 hasConcept C203014093 @default.
- W2296943863 hasConcept C2780269544 @default.
- W2296943863 hasConcept C40767141 @default.
- W2296943863 hasConcept C55493867 @default.
- W2296943863 hasConcept C71924100 @default.
- W2296943863 hasConcept C98274493 @default.
- W2296943863 hasConceptScore W2296943863C104317684 @default.
- W2296943863 hasConceptScore W2296943863C185592680 @default.
- W2296943863 hasConceptScore W2296943863C203014093 @default.
- W2296943863 hasConceptScore W2296943863C2780269544 @default.
- W2296943863 hasConceptScore W2296943863C40767141 @default.
- W2296943863 hasConceptScore W2296943863C55493867 @default.
- W2296943863 hasConceptScore W2296943863C71924100 @default.
- W2296943863 hasConceptScore W2296943863C98274493 @default.
- W2296943863 hasIssue "3" @default.
- W2296943863 hasLocation W22969438631 @default.
- W2296943863 hasOpenAccess W2296943863 @default.
- W2296943863 hasPrimaryLocation W22969438631 @default.
- W2296943863 hasRelatedWork W2007097213 @default.
- W2296943863 hasRelatedWork W2017134723 @default.
- W2296943863 hasRelatedWork W2051191062 @default.
- W2296943863 hasRelatedWork W2162452568 @default.
- W2296943863 hasRelatedWork W2388674530 @default.
- W2296943863 hasRelatedWork W2537847647 @default.
- W2296943863 hasRelatedWork W2731053579 @default.
- W2296943863 hasRelatedWork W2899084033 @default.
- W2296943863 hasRelatedWork W2982199195 @default.
- W2296943863 hasRelatedWork W4245947258 @default.
- W2296943863 hasVolume "8" @default.
- W2296943863 isParatext "false" @default.
- W2296943863 isRetracted "false" @default.
- W2296943863 magId "2296943863" @default.
- W2296943863 workType "article" @default.