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- W2296953181 abstract "Abstract Aims Despite increasing research efforts, the prognostic consequences of takotsubo cardiomyopathy ( TTC ) remain largely unknown. The aim of this study was therefore to compare the long‐term mortality rate of TTC patients with high‐risk patients presenting with ST ‐segment elevation myocardial infarction ( STEMI ). Methods and results A total of 286 patients with TTC were matched for age and gender with 286 STEMI patients. Outcome was obtained with a standardized telephone follow‐up. The primary analysis determined long‐term mortality. A secondary analysis was performed evaluating 28‐day and 1‐year mortality. Follow‐up was available for 96% of patients after a mean of 3.8 ± 2.5 years. In TTC patients, long‐term mortality was significantly higher compared with the matched STEMI cohort [24.7% vs. 15.1%, hazard ratio ( HR ) 1.58, 95% confidence interval ( CI ) 1.07–2.33; P = 0.02]. There was no significant difference in the rates of 28‐day (5.5% vs. 5.7%, HR 0.96, 95% CI 0.47–1.94; P = 0.91) and 1‐year mortality (12.5% vs. 9%, HR 1.42, 95% CI 0.85–2.38; P = 0.18). In multivariable regression analysis, male sex, a high Killip class on admission, and diabetes mellitus were identified as independent predictors of mortality in TTC patients. A risk score consisting of these factors showed a higher mortality with an increasing number of risk factors. Conclusion Mortality rates in TTC patients are higher than previously expected and long‐term mortality exceeded that of patients with STEMI . A simple risk score may provide an approach to identify high‐risk patients and predict clinical prognosis." @default.
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- W2296953181 date "2016-03-14" @default.
- W2296953181 modified "2023-10-18" @default.
- W2296953181 title "Long‐term excess mortality in takotsubo cardiomyopathy: predictors, causes and clinical consequences" @default.
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- W2296953181 doi "https://doi.org/10.1002/ejhf.494" @default.
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