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• W2296955972 endingPage "15999" @default.
• W2296955972 startingPage "15996" @default.
• W2296955972 abstract "RNA is an attractive biomolecule for biosensing and engineering applications due to its information storage capacity and ability to drive gene expression or knockdown. However, methods to link chemical signals to the production of specific RNAs are lacking. Here, we develop protease-responsive RNA polymerases (PRs) as a strategy to encode multiple specific proteolytic events in defined sequences of RNA in live mammalian cells. This work demonstrates that RNAP-based molecular recording devices can be deployed for multimodal analyses of biochemical activities or to trigger gene circuits using measured signaling events." @default.
• W2296955972 created "2016-06-24" @default.
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• W2296955972 date "2015-12-17" @default.
• W2296955972 modified "2023-09-23" @default.
• W2296955972 title "A Panel of Protease-Responsive RNA Polymerases Respond to Biochemical Signals by Production of Defined RNA Outputs in Live Cells" @default.
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• W2296955972 doi "https://doi.org/10.1021/jacs.5b10290" @default.
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