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- W2296957155 abstract "The cellular and molecular mechanisms contributing to the pathogenesis of chronic thromboembolic pulmonary hypertension (CTEPH) remain poorly understood. This study characterizes ion channels present in multipotent mesenchymal progenitor cells (MPC) isolated from endarterectomized tissue from patients with CTEPH. A population of myofibroblast-like cells expressing MPC markers (CD29, CD44, CD73, CD90, CD105, CD166) was identified. These cells formed CUF-F-like colonies and were capable of adipogenic, myogenic and osteogenic differentiation. Whole-cell patch clamp technique was used to isolate K+, Ca2+ and nonselective cation currents (NSCC). Four kinetically different voltage-dependent K+ currents (Kv) were recorded and inhibited by 4-AP and TEA. In the absence of extracellular Ca2+, IBTX-sensitive BKCa currents were detected at membrane potentials >+40mV. Many cells exhibited large NSCC, sensitive to H+ and La3+, but relatively insensitive to 2-APB and niflumic acid, with a linear current-voltage relationship reversing at 0 mV. No voltage-dependent Ca2+ currents were detected. Enhanced expression and oscillatory activity of the Na+-Ca2+ exchanger (NCX) was observed. The electrophysiological profile of these MPC may suggest a novel pathway for elevation of intracellular Ca2+. Large NSCC may elevate cytosolic Na+, activating the reverse mode NCX to further increase Ca2+ and contribute to remodeling of the pulmonary arteries in CTEPH patients. Funding source: NIH/NHLBI and CIRM Postdoctoral Fellowship" @default.
- W2296957155 created "2016-06-24" @default.
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- W2296957155 date "2010-04-01" @default.
- W2296957155 modified "2023-09-27" @default.
- W2296957155 title "Characterization of Ion Channels in Progenitor Cells Isolated From CTEPH Patients" @default.
- W2296957155 doi "https://doi.org/10.1096/fasebj.24.1_supplement.1023.25" @default.
- W2296957155 hasPublicationYear "2010" @default.
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