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• W2296957975 abstract "2 Summary Allergic inflammation is associated with an increased Type 2 helper T cell (Th2) response, including secretion of Th2 cytokines and IgE antibody. Reduction of allergic reaction is occurs due to an increase in Th1 immune responses to restrain Th2 via the secretion of the TNF-α and IL-12. Probiotics are believed to alleviate allergic reactions by improving intestinal microbial balance. We examined anti-allergenic effects of probiotics Aspergillus oryzae (AO) and Lactobacillus sakei (LS) in a murine macrophage cell line J774.1 and a mouse model of ovalbumin (OVA)- induced allergy. The treatment with AO and LS induced the secretion of Th1 response-related cytokines tumor necrosis factor-α (TNF-α) and interleukin-12 (IL-12) in macrophages and signif- icantly reduced the production of anti-OVA IgE and proliferative activity of splenocytes in OVA- induced allergic mice. Our results suggest that the tested probiotics can reduce allergic immune reactions by upregulating Th1 and downregulating Th2 response via secretion of TNF-α and IL-12. These observations may be useful for the management of food and/or environmental allergic reactions in humans." @default.
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• W2296957975 date "2015-12-01" @default.
• W2296957975 modified "2023-09-27" @default.
• W2296957975 title "Probiotics Aspergillus oryzae and Lactobacillus sakei reduce IgE and increase Th1 cytokines in an ovalbumin-induced murine model of allergy" @default.
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