Matches in SemOpenAlex for { <https://semopenalex.org/work/W2296960529> ?p ?o ?g. }
- W2296960529 endingPage "830" @default.
- W2296960529 startingPage "825" @default.
- W2296960529 abstract "Carcinogenesis, the formation of solid tumors, is now widely accepted to represent a multistep process. Several genetic events, activation of proto-oncogenes and inactivation of tumor suppressor genes, are involved.Review of the literature for evidence that the concept of multistep transformation has relevance also for the formation of low-grade lymphoproliferative diseases.The common translocations in low-grade lymphoid tumors are probably early events, predominantly involved in the activation of oncogenes, leading to growth stimulation or prolonged cell survival. As a result 'monoclonal lymphoproliferative disorders of undetermined significance (MLDUS)' occur, undetermined, because some translocations may not always led to tumor formation. For progression to full malignancy, additional genetic events are required besides sequential selection of variant subpopulations within the neoplastic clone. Recent data indicate that mutations and deletions of putative tumor suppressor genes, including the P53 and retinoblastoma genes, are also involved in the progression of lymphoproliferative disorders. A list of lymphoproliferative diseases stressing this concept of multistep transformation is presented in this article." @default.
- W2296960529 created "2016-06-24" @default.
- W2296960529 creator A5025839938 @default.
- W2296960529 creator A5052575530 @default.
- W2296960529 creator A5060842889 @default.
- W2296960529 date "1993-12-01" @default.
- W2296960529 modified "2023-10-18" @default.
- W2296960529 title "Multistep transformation in low-grade lymphoproliferative diseases" @default.
- W2296960529 cites W1557938671 @default.
- W2296960529 cites W1577776864 @default.
- W2296960529 cites W1820787401 @default.
- W2296960529 cites W1952186440 @default.
- W2296960529 cites W1967861547 @default.
- W2296960529 cites W1970032195 @default.
- W2296960529 cites W1975871422 @default.
- W2296960529 cites W1979618971 @default.
- W2296960529 cites W1980847511 @default.
- W2296960529 cites W1987460795 @default.
- W2296960529 cites W1988814351 @default.
- W2296960529 cites W1994007079 @default.
- W2296960529 cites W1995775226 @default.
- W2296960529 cites W1996086834 @default.
- W2296960529 cites W1996449685 @default.
- W2296960529 cites W2001258296 @default.
- W2296960529 cites W2002251558 @default.
- W2296960529 cites W2006486191 @default.
- W2296960529 cites W2009183764 @default.
- W2296960529 cites W2012770211 @default.
- W2296960529 cites W2022329296 @default.
- W2296960529 cites W2027506631 @default.
- W2296960529 cites W2028673078 @default.
- W2296960529 cites W2030789354 @default.
- W2296960529 cites W2036036317 @default.
- W2296960529 cites W2041418928 @default.
- W2296960529 cites W2043807984 @default.
- W2296960529 cites W2046933609 @default.
- W2296960529 cites W2047748450 @default.
- W2296960529 cites W2048835029 @default.
- W2296960529 cites W2051296872 @default.
- W2296960529 cites W2053119119 @default.
- W2296960529 cites W2056163856 @default.
- W2296960529 cites W2057257609 @default.
- W2296960529 cites W2057805027 @default.
- W2296960529 cites W2057918521 @default.
- W2296960529 cites W2066380000 @default.
- W2296960529 cites W2068909560 @default.
- W2296960529 cites W2074114480 @default.
- W2296960529 cites W2079692146 @default.
- W2296960529 cites W2093193204 @default.
- W2296960529 cites W2099313138 @default.
- W2296960529 cites W2117706980 @default.
- W2296960529 cites W2126679757 @default.
- W2296960529 cites W2142693274 @default.
- W2296960529 cites W2152432521 @default.
- W2296960529 cites W2174418452 @default.
- W2296960529 cites W2318225391 @default.
- W2296960529 cites W2324023748 @default.
- W2296960529 cites W2328842291 @default.
- W2296960529 cites W2332394549 @default.
- W2296960529 cites W2335864563 @default.
- W2296960529 cites W2381926878 @default.
- W2296960529 cites W2410783213 @default.
- W2296960529 cites W2416529880 @default.
- W2296960529 cites W4230271494 @default.
- W2296960529 cites W4244620058 @default.
- W2296960529 cites W5489242 @default.
- W2296960529 cites W87643924 @default.
- W2296960529 doi "https://doi.org/10.1093/oxfordjournals.annonc.a058387" @default.
- W2296960529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8117601" @default.
- W2296960529 hasPublicationYear "1993" @default.
- W2296960529 type Work @default.
- W2296960529 sameAs 2296960529 @default.
- W2296960529 citedByCount "28" @default.
- W2296960529 crossrefType "journal-article" @default.
- W2296960529 hasAuthorship W2296960529A5025839938 @default.
- W2296960529 hasAuthorship W2296960529A5052575530 @default.
- W2296960529 hasAuthorship W2296960529A5060842889 @default.
- W2296960529 hasBestOaLocation W22969605291 @default.
- W2296960529 hasConcept C104317684 @default.
- W2296960529 hasConcept C138626823 @default.
- W2296960529 hasConcept C142724271 @default.
- W2296960529 hasConcept C203014093 @default.
- W2296960529 hasConcept C2776577112 @default.
- W2296960529 hasConcept C2776995267 @default.
- W2296960529 hasConcept C2779338263 @default.
- W2296960529 hasConcept C2779399171 @default.
- W2296960529 hasConcept C2993273003 @default.
- W2296960529 hasConcept C31033888 @default.
- W2296960529 hasConcept C502942594 @default.
- W2296960529 hasConcept C54355233 @default.
- W2296960529 hasConcept C555283112 @default.
- W2296960529 hasConcept C71924100 @default.
- W2296960529 hasConcept C81089528 @default.
- W2296960529 hasConcept C86803240 @default.
- W2296960529 hasConceptScore W2296960529C104317684 @default.
- W2296960529 hasConceptScore W2296960529C138626823 @default.
- W2296960529 hasConceptScore W2296960529C142724271 @default.
- W2296960529 hasConceptScore W2296960529C203014093 @default.