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- W2296964964 abstract "The intestinal mucosa permits the absorption of vital nutrients from the gastrointestinal lumen in addition to providing a barrier against the passage of pathogenic substances into the body. The term Intestinal Permeability (IP) represents a defect in barrier function. This defect results in large molecules of undigested food, microbiota and intestinally derived endotoxins passing through or between the tight junctions of the intestine, activating inflammatory and aberrant immune responses. Defects in intestinal barrier function have been associated with ankylosing spondylitis, atopic dermatitis, Coeliac disease, Crohn's disease, chronic heart failure, Chronic Fatigue Syndrome, cancer, diarrhoeapredominant Irritable Bowel Syndrome, depression, food allergy, inflammatory joint disease, juvenile onset arthritis, liver cirrhosis, psoriatic arthritis and mental health issues. The increase in publications dedicated to intestinal barrier defects and disease has shifted intestinal permeability away from a concept category to a recognised and well described pathophysiological state. This technical review article is one of a two part series that aims to review the important function of the gastrointestinal associated lymphoid tissue (GALT) and dysfunctions that can lead to IP. Part Two will review the role of probiotics and nutrition in the clinical management of IP." @default.
- W2296964964 created "2016-06-24" @default.
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- W2296964964 date "2013-09-01" @default.
- W2296964964 modified "2023-09-25" @default.
- W2296964964 title "Understanding the intricacies of intestinal immunity: Integral to nutritional medicine practice" @default.
- W2296964964 hasPublicationYear "2013" @default.
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