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- W2296972078 abstract "Circulating markers relevant to the development of abdominal aortic aneurysm (AAA) are currently required. Lipoprotein(a), Lp(a), is considered a candidate marker associated with the presence of AAA. The present meta-analysis aimed to evaluate the association between circulating Lp(a) levels and the presence of AAA. The PubMed-based search was conducted up to April 30, 2015, to identify the studies focusing on Lp(a) levels in patients with AAA and controls. Quantitative data synthesis was performed using a random effects model, with standardized mean difference (SMD) and 95% confidence interval (CI) as summary statistics. Overall, 9 studies were identified. After a combined analysis, patients with AAA were found to have a significantly higher level of Lp(a) compared to the controls (SMD: 0.87, 95% CI: 0.41-1.33, P < .001). This result remained robust in the sensitivity analysis, and its significance was not influenced after omitting each of the included studies from the meta-analysis. The present meta-analysis confirmed a higher level of circulating Lp(a) in patients with AAA compared to controls. High Lp(a) levels can be associated with the presence of AAA, and Lp(a) may be a marker in screening for AAA. Further studies are needed to establish the clinical utility of measuring Lp(a) in the prevention and management of AAA." @default.
- W2296972078 created "2016-06-24" @default.
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- W2296972078 date "2016-09-29" @default.
- W2296972078 modified "2023-09-27" @default.
- W2296972078 title "Lipoprotein(a) Levels in Patients With Abdominal Aortic Aneurysm" @default.
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- W2296972078 doi "https://doi.org/10.1177/0003319716637792" @default.
- W2296972078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26980774" @default.
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