FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2296975830> ?p ?o ?g. }

• W2296975830 endingPage "87" @default.
• W2296975830 startingPage "82" @default.
• W2296975830 abstract "Tenascin C (TNC) is an extracellular matrix glycoprotein involved in osteogenesis and bone mineralization. In a previous study, we identified TNC protein located in the matrix vesicles (MVs) of osteoblasts. MVs are determinant in the mineralization formation. Therefore, we hypothesize whether TNC can modulate osteoblast mineralization via MVs. In this study, we demonstrated that the expression level of TNC was increased with osteoblast differentiation of osteoblast-like SaOS2 cells, and down-regulation of TNC expression by siRNA could significantly inhibit SaOS2 differentiation toward osteoblasts and mineralization as evidenced by decreases in ALP activity, mineralized nodule formation, calcium deposition, and down-regulation of osteogenic marker genes ALP, and COL1A1. Furthermore, we validated that TNC located in the MVs of mineralized SaOS2 cells, and that down-regulation of TNC could decrease MVs mineralization ability in vitro, and the decrease of MVs mineralization ability was not associated with annexins. In conclusion, in this study, we extended the role of TNC during osteogenesis previous progresses, and that supported TNC as an important functional MVs component in modulating osteoblast mineralization." @default.
• W2296975830 created "2016-06-24" @default.
• W2296975830 creator A5010369475 @default.
• W2296975830 creator A5011715666 @default.
• W2296975830 creator A5017829182 @default.
• W2296975830 creator A5031517832 @default.
• W2296975830 creator A5073548994 @default.
• W2296975830 creator A5079524437 @default.
• W2296975830 creator A5089205591 @default.
• W2296975830 creator A5089271628 @default.
• W2296975830 date "2016-01-01" @default.
• W2296975830 modified "2023-10-16" @default.
• W2296975830 title "Tenascin C affects mineralization of SaOS2 osteoblast-like cells through matrix vesicles" @default.
• W2296975830 cites W1521608629 @default.
• W2296975830 cites W1781326613 @default.
• W2296975830 cites W1894624738 @default.
• W2296975830 cites W1899123775 @default.
• W2296975830 cites W1963560266 @default.
• W2296975830 cites W1966395405 @default.
• W2296975830 cites W1972050610 @default.
• W2296975830 cites W2002113583 @default.
• W2296975830 cites W2002136685 @default.
• W2296975830 cites W2016476443 @default.
• W2296975830 cites W2029534006 @default.
• W2296975830 cites W2030332518 @default.
• W2296975830 cites W2037960315 @default.
• W2296975830 cites W2040780797 @default.
• W2296975830 cites W2062811107 @default.
• W2296975830 cites W2074621479 @default.
• W2296975830 cites W2076540633 @default.
• W2296975830 cites W2076663459 @default.
• W2296975830 cites W2101619182 @default.
• W2296975830 cites W2142572358 @default.
• W2296975830 cites W2150049401 @default.
• W2296975830 cites W343808865 @default.
• W2296975830 doi "https://doi.org/10.5582/ddt.2016.01009" @default.
• W2296975830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26961327" @default.
• W2296975830 hasPublicationYear "2016" @default.
• W2296975830 type Work @default.
• W2296975830 sameAs 2296975830 @default.
• W2296975830 citedByCount "13" @default.
• W2296975830 countsByYear W22969758302017 @default.
• W2296975830 countsByYear W22969758302018 @default.
• W2296975830 countsByYear W22969758302019 @default.
• W2296975830 countsByYear W22969758302020 @default.
• W2296975830 countsByYear W22969758302021 @default.
• W2296975830 countsByYear W22969758302023 @default.
• W2296975830 crossrefType "journal-article" @default.
• W2296975830 hasAuthorship W2296975830A5010369475 @default.
• W2296975830 hasAuthorship W2296975830A5011715666 @default.
• W2296975830 hasAuthorship W2296975830A5017829182 @default.
• W2296975830 hasAuthorship W2296975830A5031517832 @default.
• W2296975830 hasAuthorship W2296975830A5073548994 @default.
• W2296975830 hasAuthorship W2296975830A5079524437 @default.
• W2296975830 hasAuthorship W2296975830A5089205591 @default.
• W2296975830 hasAuthorship W2296975830A5089271628 @default.
• W2296975830 hasBestOaLocation W22969758301 @default.
• W2296975830 hasConcept C111696902 @default.
• W2296975830 hasConcept C160160445 @default.
• W2296975830 hasConcept C178790620 @default.
• W2296975830 hasConcept C181199279 @default.
• W2296975830 hasConcept C185592680 @default.
• W2296975830 hasConcept C189165786 @default.
• W2296975830 hasConcept C202751555 @default.
• W2296975830 hasConcept C2778260815 @default.
• W2296975830 hasConcept C537208039 @default.
• W2296975830 hasConcept C55493867 @default.
• W2296975830 hasConcept C86803240 @default.
• W2296975830 hasConcept C95444343 @default.
• W2296975830 hasConceptScore W2296975830C111696902 @default.
• W2296975830 hasConceptScore W2296975830C160160445 @default.
• W2296975830 hasConceptScore W2296975830C178790620 @default.
• W2296975830 hasConceptScore W2296975830C181199279 @default.
• W2296975830 hasConceptScore W2296975830C185592680 @default.
• W2296975830 hasConceptScore W2296975830C189165786 @default.
• W2296975830 hasConceptScore W2296975830C202751555 @default.
• W2296975830 hasConceptScore W2296975830C2778260815 @default.
• W2296975830 hasConceptScore W2296975830C537208039 @default.
• W2296975830 hasConceptScore W2296975830C55493867 @default.
• W2296975830 hasConceptScore W2296975830C86803240 @default.
• W2296975830 hasConceptScore W2296975830C95444343 @default.
• W2296975830 hasIssue "2" @default.
• W2296975830 hasLocation W22969758301 @default.
• W2296975830 hasLocation W22969758302 @default.
• W2296975830 hasOpenAccess W2296975830 @default.
• W2296975830 hasPrimaryLocation W22969758301 @default.
• W2296975830 hasRelatedWork W1953162731 @default.
• W2296975830 hasRelatedWork W2004933175 @default.
• W2296975830 hasRelatedWork W2022493848 @default.
• W2296975830 hasRelatedWork W2083706866 @default.
• W2296975830 hasRelatedWork W2347665948 @default.
• W2296975830 hasRelatedWork W2349696134 @default.
• W2296975830 hasRelatedWork W2369873382 @default.
• W2296975830 hasRelatedWork W2370648588 @default.
• W2296975830 hasRelatedWork W2381932454 @default.
• W2296975830 hasRelatedWork W2384703214 @default.
• W2296975830 hasVolume "10" @default.
• W2296975830 isParatext "false" @default.

• next