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• W2296979866 endingPage "13" @default.
• W2296979866 startingPage "13" @default.
• W2296979866 abstract "All nucleic acids in cells are subject to post-transcriptional chemical modifications. These are catalyzed by a myriad of enzymes with exquisite specificity and that utilize an often-exotic array of chemical substrates. In no molecule are modifications more prevalent than in transfer RNAs. In the present document, we will attempt to take a chemical rollercoaster ride from prebiotic times to the present, with nucleoside modifications as key players and tRNA as the centerpiece that drove the evolution of biological systems to where we are today. These ideas will be put forth while touching on several examples of tRNA modification enzymes and their modus operandi in cells. In passing, we submit that the choice of tRNA is not a whimsical one but rather highlights its critical function as an essential invention for the evolution of protein enzymes." @default.
• W2296979866 created "2016-06-24" @default.
• W2296979866 creator A5031740744 @default.
• W2296979866 creator A5069816964 @default.
• W2296979866 date "2016-03-14" @default.
• W2296979866 modified "2023-10-12" @default.
• W2296979866 title "From Prebiotics to Probiotics: The Evolution and Functions of tRNA Modifications" @default.
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