FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2296989255> ?p ?o ?g. }

• W2296989255 endingPage "584" @default.
• W2296989255 startingPage "574" @default.
• W2296989255 abstract "Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available.In this multicentre, cohort study, we collected data about patients (age ≥16 years old) with clinically isolated syndrome, relapsing-remitting multiple sclerosis, and progressive multiple sclerosis. Patients were recruited from centres in Spain, Italy, France, Germany, Czech Republic, Netherlands, Canada, and the USA, with the first cohort starting in 2008 and the latest cohort starting in 2013. We assessed disability worsening using the Expanded Disability Status Scale (EDSS). The pRNFL thickness and macular volume were assessed once at study entry (baseline) by optical coherence tomography (OCT) and was calculated as the mean value of both eyes without optic neuritis for patients without a history of optic neuritis or the value of the non-optic neuritis eye for patients with previous unilateral optic neuritis. Researchers who did the OCT at baseline were masked to EDSS results and the researchers assessing disability with EDSS were masked to OCT results. We estimated the association of pRNFL thickness or macular volume at baseline in eyes without optic neuritis with the risk of subsequent disability worsening by use of proportional hazards models that included OCT metrics and age, disease duration, disability, presence of previous unilateral optic neuritis, and use of disease-modifying therapies as covariates.879 patients with clinically isolated syndrome (n=74), relapsing-remitting multiple sclerosis (n=664), or progressive multiple sclerosis (n=141) were included in the primary analyses. Disability worsening occurred in 252 (29%) of 879 patients with multiple sclerosis after a median follow-up of 2·0 years (range 0·5-5 years). Patients with a pRNFL of less than or equal to 87 μm or less than or equal to 88 μm (measured with Spectralis or Cirrus OCT devices) had double the risk of disability worsening at any time after the first and up to the third years of follow-up (hazard ratio 2·06, 95% CI 1·36-3·11; p=0·001), and the risk was increased by nearly four times after the third and up to the fifth years of follow-up (3·81, 1·63-8·91; p=0·002). We did not identify meaningful associations for macular volume.Our results provide evidence of the usefulness of monitoring pRNFL thickness by OCT for prediction of the risk of disability worsening with time in patients with multiple sclerosis.Instituto de Salud Carlos III." @default.
• W2296989255 created "2016-06-24" @default.
• W2296989255 creator A5000146107 @default.
• W2296989255 creator A5002621424 @default.
• W2296989255 creator A5009520384 @default.
• W2296989255 creator A5011728381 @default.
• W2296989255 creator A5012275404 @default.
• W2296989255 creator A5012449119 @default.
• W2296989255 creator A5013357095 @default.
• W2296989255 creator A5015094639 @default.
• W2296989255 creator A5015867530 @default.
• W2296989255 creator A5018421742 @default.
• W2296989255 creator A5023239670 @default.
• W2296989255 creator A5025462803 @default.
• W2296989255 creator A5027426814 @default.
• W2296989255 creator A5036861819 @default.
• W2296989255 creator A5038030903 @default.
• W2296989255 creator A5042888061 @default.
• W2296989255 creator A5043499649 @default.
• W2296989255 creator A5043687800 @default.
• W2296989255 creator A5045206632 @default.
• W2296989255 creator A5046354840 @default.
• W2296989255 creator A5047859644 @default.
• W2296989255 creator A5048881912 @default.
• W2296989255 creator A5051446807 @default.
• W2296989255 creator A5052025260 @default.
• W2296989255 creator A5055982046 @default.
• W2296989255 creator A5056912783 @default.
• W2296989255 creator A5057457747 @default.
• W2296989255 creator A5058205908 @default.
• W2296989255 creator A5059824595 @default.
• W2296989255 creator A5061751725 @default.
• W2296989255 creator A5061851273 @default.
• W2296989255 creator A5062060255 @default.
• W2296989255 creator A5065822870 @default.
• W2296989255 creator A5071972650 @default.
• W2296989255 creator A5072712902 @default.
• W2296989255 creator A5074560237 @default.
• W2296989255 creator A5077200649 @default.
• W2296989255 creator A5078067575 @default.
• W2296989255 creator A5079276092 @default.
• W2296989255 creator A5080686072 @default.
• W2296989255 creator A5083602174 @default.
• W2296989255 creator A5088301395 @default.
• W2296989255 creator A5089004523 @default.
• W2296989255 date "2016-05-01" @default.
• W2296989255 modified "2023-10-15" @default.
• W2296989255 title "Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study" @default.
• W2296989255 cites W1018609964 @default.
• W2296989255 cites W1828579964 @default.
• W2296989255 cites W1867586965 @default.
• W2296989255 cites W1914231371 @default.
• W2296989255 cites W1955700682 @default.
• W2296989255 cites W1970663794 @default.
• W2296989255 cites W1978234346 @default.
• W2296989255 cites W1982245010 @default.
• W2296989255 cites W2000511084 @default.
• W2296989255 cites W2008706768 @default.
• W2296989255 cites W2026913491 @default.
• W2296989255 cites W2026956757 @default.
• W2296989255 cites W2035237217 @default.
• W2296989255 cites W2038177799 @default.
• W2296989255 cites W2050946840 @default.
• W2296989255 cites W2057911576 @default.
• W2296989255 cites W2063980734 @default.
• W2296989255 cites W2070532347 @default.
• W2296989255 cites W2084139018 @default.
• W2296989255 cites W2086091627 @default.
• W2296989255 cites W2091683461 @default.
• W2296989255 cites W2105206040 @default.
• W2296989255 cites W2112165124 @default.
• W2296989255 cites W2115404493 @default.
• W2296989255 cites W2122237804 @default.
• W2296989255 cites W2122545833 @default.
• W2296989255 cites W2130124844 @default.
• W2296989255 cites W2136325849 @default.
• W2296989255 cites W2137327465 @default.
• W2296989255 cites W2142457016 @default.
• W2296989255 cites W2142655452 @default.
• W2296989255 cites W2144665769 @default.
• W2296989255 cites W2145468787 @default.
• W2296989255 cites W2265767893 @default.
• W2296989255 doi "https://doi.org/10.1016/s1474-4422(16)00068-5" @default.
• W2296989255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27011339" @default.
• W2296989255 hasPublicationYear "2016" @default.
• W2296989255 type Work @default.
• W2296989255 sameAs 2296989255 @default.
• W2296989255 citedByCount "241" @default.
• W2296989255 countsByYear W22969892552015 @default.
• W2296989255 countsByYear W22969892552016 @default.
• W2296989255 countsByYear W22969892552017 @default.
• W2296989255 countsByYear W22969892552018 @default.
• W2296989255 countsByYear W22969892552019 @default.
• W2296989255 countsByYear W22969892552020 @default.
• W2296989255 countsByYear W22969892552021 @default.
• W2296989255 countsByYear W22969892552022 @default.
• W2296989255 countsByYear W22969892552023 @default.
• W2296989255 crossrefType "journal-article" @default.

• next